Effect of acute hyperglycaemia on sensory processing in diabetic autonomic neuropathy
Effect of acute hyperglycaemia on sensory processing in diabetic autonomic neuropathy
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DOI：
10.1111/j.1365-2362.2010.02335.x
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发表时间：
2010-10-01
影响因子：
5.5
通讯作者：
Drewes, Asbjorn M.
中科院分区：
文献类型：
--
作者：
Frokjaer, Jens B.;Softeland, Eirik;Drewes, Asbjorn M.
背景急性高血糖症可增加健康人的胃肠道敏感性，并可能导致糖尿病患者胃肠道症状的发生率增加。本研究的目的是评估急性高血压对糖尿病患者感知和脑对疼痛的内脏和躯体刺激的反应的影响。材料和方法对14例糖尿病患者进行了食管和正中神经电刺激敏感性和诱发脑电位（EP）的评估。1例伴有自主神经病变和GI症状的糖尿病患者使用6和15 mM的高胰岛素钳夹。而高血糖状态对食管（P = 0，中点72）和正中神经（P = 0，中点66）刺激均敏感。正常和高血压的条件下食管（P = 0中心点53和0中心点57）和正中神经（P = 0中心点78和0中心点52）stimulations.ConclusionsAcute hyperemia本身并不有助于长期糖尿病和自主神经病变的患者的感觉之间的潜伏期和幅度的EP没有差异。急性高血糖症的任何潜在感觉效应可能会被感觉神经系统中的神经病样变化所模糊。
P>BackgroundAcute hyperglycaemia is known to increase gastrointestinal (GI) sensitivity in healthy subjects and may contribute to the increased prevalence of GI symptoms in diabetes patients. The aim of this study was to evaluate the effect of acute hyperglycaemia on perception and brain responses to painful visceral and somatic stimuli in diabetic patients.Materials and methodsThe sensitivity and evoked brain potentials (EPs) to electrical oesophageal and median nerve stimulations were assessed in 14 type-1 diabetes patients with autonomic neuropathy and GI symptoms using a hyperinsulinaemic clamp at 6 and 15 mM.ResultsNo differences between the normo- and hyperglycaemic conditions were found in sensitivity to both oesophageal (P = 0 center dot 72) and median nerve (P = 0 center dot 66) stimulations. The latencies and amplitudes of EPs did not differ between the normo- and hyperglycaemic conditions following oesophageal (P = 0 center dot 53 and 0 center dot 57) and median nerve (P = 0 center dot 78 and 0 center dot 52) stimulations.ConclusionsAcute hyperglycaemia itself does not contribute to the sensations in patients with longstanding diabetes and autonomic neuropathy. Any potential sensory effects of acute hyperglycaemia can likely be blurred by the neuropathic-like changes in the sensory nervous system.