Interaction between tachykinins and CGRP in human skin.
Interaction between tachykinins and CGRP in human skin.
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人体皮肤中速激肽和 CGRP 之间的相互作用。
DOI：
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发表时间：
1993
影响因子：
3.6
通讯作者：
Z. Y. Wang
中科院分区：
文献类型：
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作者：
J. Wallengren;Z. Y. Wang
P物质（SP）、神经激肽A（NKA）和降钙素基因相关肽（CGRP）共存于皮肤的神经纤维中。CGRP在皮内注射后引起红斑。红斑不依赖于轴突反射和肥大细胞组胺的释放。已知SP产生依赖于轴突反射和肥大细胞组胺释放的爆发反应。已知对NKA的耀斑反应主要取决于轴突反射。本研究的目的是探讨SP和CGRP之间可能的合作。发现SP缩短伴随注射CGRP引起的发红的持续时间。NKA不缩短CGRP反应的持续时间。通过用化合物48/80处理局部消除皮肤中的肥大细胞具有使SP丧失其缩短CGRP诱发的红斑的能力的效果。这些观察结果支持的建议，SP诱发的释放蛋白水解酶的肥大细胞可能会导致加速降解的CGRP。
Substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) coexist in nerve fibres in the skin. CGRP causes erythema upon intracutaneous injection. The erythema is independent of axon reflexes and release of mast cell histamine. SP is known to produce a flare reaction that is dependent on axon reflexes and release of mast cell histamine. The flare reaction to NKA is known to depend predominantly on axon reflexes. The purpose of the present study was to investigate possible cooperation between SP and CGRP. SP was found to shorten the duration of the reddening induced by CGRP, injected concomitantly. NKA did not shorten the duration of the CGRP response. Local elimination of mast cells in the skin by treatment with compound 48/80 had the effect that SP lost its ability to shorten CGRP-evoked erythema. These observations support the suggestion that an SP-evoked release of proteolytic enzymes from mast cells could lead to accelerated degradation of CGRP.