Epigenetic Control of Embryonic Stem Cell Differentiation
Epigenetic Control of Embryonic Stem Cell Differentiation
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DOI：
10.1007/s12015-011-9300-4
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发表时间：
2012-03-01
影响因子：
4.8
通讯作者：
Armstrong, Lyle
中科院分区：
文献类型：
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作者：
Armstrong, Lyle
多能胚胎干细胞可以产生几乎所有体细胞类型，但这一特性需要精确控制其基因表达模式。保持整个基因组“准备好”进入多种发育可能性中的任何一种的必要性需要基于组蛋白修饰的特定模式的独特且高度可塑的染色质组织，尽管这种状态在胚胎发育期间通常是短暂的。通过从早期胚胎中提取胚胎干细胞，我们可以保留高度专业化的基因组组织，这使得可以对多能性的分子基础进行一些详细的研究。
Pluripotent embryonic stem cells can give rise to almost all somatic cell types but this characteristic requires precise control of their gene expression patterns. The necessity of keeping the entire genome "poised" to enter into any of a number of developmental possibilities requires a unique and highly plastic chromatin organisation based around specific patterns of histone modifications although this state of affairs is normally short lived during embryonic development. By deriving embryonic stem cells from the early embryo, we can preserve the highly specialised genome organisation and this has permitted several detailed investigations into the molecular basis of pluripotency.