Recent trends of biomaterials and biosensors for organ-on-chip platforms
Recent trends of biomaterials and biosensors for organ-on-chip platforms
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DOI：
10.1016/j.bprint.2022.e00202
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发表时间：
2022-06-01
期刊：
影响因子：
--
通讯作者：
Minas, Graca
中科院分区：
文献类型：
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作者：
Goncalves, Ines M.;Rodrigues, Raquel O.;Minas, Graca
器官芯片（OoC）平台是一类新型先进的微流体设备，由于模仿人体器官模型，可以更快、更针对患者地评估药物的效果，因此引起了药物开发的极大关注。与大多数微流体装置一样，绝大多数 OoC 由聚二甲基硅氧烷 (PDMS) 制成，因为其易于处理且具有物理化学特性。然而，PDMS 可以滤出未交联的低聚物并吸收小的疏水性分子，这使其不太适合细胞培养。在这项工作中，我们回顾了与 PDMS 一起使用或替代 PDMS 来制造 OoC 平台的不同类型的材料。几项研究已经复制了差异化结构及其关键生理功能，例如肌肉收缩、皮肤弹性和变形性、肺泡囊中的气体交换、电刺激，甚至监测芯片内部的微环境。因此，在本次综述中，对 OoC 平台的最新进展进行了修订，包括从最终用途的角度进行生物传感器的制造和小型化。
Organ-on-chip (OoC) platforms are a new class of advanced microfluidic devices that have been attracting significant attention for drug development since they can allow a faster and more patient specific evaluation of the effects of drugs due to the mimicking of organ human models. As most microfluidic devices, the great majority of the OoC is made from polydimethylsiloxane (PDMS), due to the easiness to handle and due to its physicochemical properties. Nevertheless, PDMS can leach uncrosslinked oligomer and absorb small hydrophobic molecules, which makes it less suitable for cell culture. In this work, we review different kinds of materials that are used together with, or in replacement, of PDMS to manufacture the OoC platforms. Several studies have replicated differentiated structures and their key physiological functions, such as muscle contraction, skin elasticity and deformability, gas exchange in alveolar sacs, electrical stimulation or even to monitor the microenvironment, inside the chip. Therefore, in this Review, recent advances on OoC platforms, including fabrication and miniaturization of biosensors for an end-use perspective are revised.