Multiple melanocytic nevi restricted to mycosis fungoides patches in pediatric and young-adult patients. The potential role of local immunosuppression.
Multiple melanocytic nevi restricted to mycosis fungoides patches in pediatric and young-adult patients. The potential role of local immunosuppression.
复制标题
儿童和年轻成人患者的多发性黑素细胞痣仅限于蕈样肉芽肿斑片。
DOI：
10.1111/pde.13738
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发表时间：
2019
影响因子：
1.5
通讯作者：
Guitart,Joan
中科院分区：
文献类型：
--
作者：
Martinez-Escala,MariaEstela;Amin,SapnaModi;Sable,KimberlyAnne;Gerami,Pedram;Guitart,Joan
我们描述了四名年轻患者在长期MF贴片中出现多发性黑素细胞痣的发展。蕈样真菌病（MF）贴片的特点是调节样细胞因子谱导致局部免疫抑制。新黑素细胞的增殖受免疫系统介导的细胞衰老机制的调控。MF浸润的免疫抑制作用与治疗的全身效应相结合，可能在本文所述患者的新瘤发生中起特定作用。
We described the development of multiple melanocytic nevi within long‐standing MF patches in four young patients. Mycosis fungoides (MF) patches are characterized by a regulatory‐like cytokine profile leading to local immune suppression. The proliferation of nevomelanocytes is regulated by cellular senescence mechanisms mediated by immune system. The immunosuppressive effect of MF infiltrate in conjunction with the systemic effect of treatments may play a specific role in the nevomelanogenesis of the patients herein described.