Molecular imaging: a promising tool to monitor islet transplantation.
Molecular imaging: a promising tool to monitor islet transplantation.
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DOI：
10.1155/2011/202915
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发表时间：
2011
影响因子：
2.5
通讯作者：
Moore A
中科院分区：
文献类型：
--
作者：
Wang P;Medarova Z;Moore A
通过胰岛移植替代胰岛素产生作为1型糖尿病的治疗具有巨大的潜力。目前，缺乏一种有效的方法来评估胰岛移植限制了这种治疗的成功。分子影像学技术的发展有可能实现实时无创监测胰岛移植物的功能状态和活性的目标。我们回顾了各种影像学方法在检测内源性和移植β细胞团中的应用。综述还探讨了各种分子成像策略，用于评估胰岛输送，对胰岛移植物的代谢影响以及免疫排斥反应的检测。在这里，我们强调使用联合成像和治疗干预胰岛移植和在体内监测干细胞分化成胰岛素产生细胞。
Replacement of insulin production by pancreatic islet transplantation has great potential as a therapy for type 1 diabetes mellitus. At present, the lack of an effective approach to islet grafts assessment limits the success of this treatment. The development of molecular imaging techniques has the potential to fulfill the goal of real-time noninvasive monitoring of the functional status and viability of the islet grafts. We review the application of a variety of imaging modalities for detecting endogenous and transplanted beta-cell mass. The review also explores the various molecular imaging strategies for assessing islet delivery, the metabolic effects on the islet grafts as well as detection of immunorejection. Here, we highlight the use of combined imaging and therapeutic interventions in islet transplantation and the in vivo monitoring of stem cells differentiation into insulin-producing cells.