Stress-induced reinstatement of amphetamine-conditioned place preference and changes in tyrosine hydroxylase in the nucleus accumbens in adolescent rats
Stress-induced reinstatement of amphetamine-conditioned place preference and changes in tyrosine hydroxylase in the nucleus accumbens in adolescent rats
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DOI：
10.1016/j.pbb.2010.05.001
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发表时间：
2010-08-01
影响因子：
3.6
通讯作者：
Planeta, Cleopatra S.
中科院分区：
文献类型：
--
作者：
Cruz, Fabio C.;Leao, Rodrigo M.;Planeta, Cleopatra S.
人类的药物滥用往往始于青春期。在这一年龄段接触精神兴奋剂可能会产生长期后果，使机体更容易滥用药物，并在以后的生活中复发。事实证明，即使在长期停药后，暴露于压力也会促进吸毒复发。条件性位置偏爱（CPP）的恢复是研究复发的有效动物模型。在人类和动物中，酪氨酸羟化酶（TN）的变化与药物成瘾有关。我们的研究探讨了是否安非他明诱导的CPP在青春期可以恢复暴露于压力1（青春期）和30（成年期）天后灭绝测试。我们还调查了TH水平恢复CPP后。我们的研究结果表明，安非他明诱导的CPP在青春期可以恢复压力暴露1天（P42，青春期结束），但不是灭绝后30天（P71，成年）。此外，恢复AMPH诱导的CPP应激暴露发生在减少TH的存在下，在延髓核。总之，我们的数据增加了新的证据表明，TH的神经适应可能介导青春期内由压力引起的药物寻求行为的复发。(C)2010年爱思唯尔公司All rights reserved.
Drug abuse among humans often begins during adolescence. Exposure to psychostimulants during this age period may have long-term consequences which can render the organism more susceptible to drug abuse and relapse later in life. It has been demonstrated that exposure to stress can promote relapse to drug use even after long periods of withdrawal. The reinstatement of conditioned place preference (CPP) is a useful animal model for studying relapse. In humans and animals, changes in tyrosine hydroxylase (TN) have been related to drug addiction. Our study examined whether amphetamine-induced CPP during adolescence could be reinstated by exposure to stress 1 (adolescence) and 30 (adulthood) days after the extinction test. We also investigated TH levels following the reinstatement of CPP. Our results showed that amphetamine-induced CPP during adolescence can be reinstated by stress exposure 1 day (P42, end of adolescence) but not 30 days after extinction (P71, adulthood). Moreover the reinstatement of AMPH-induced CPP by stress exposure occurred in the presence of decreased TH in the nucleus accumbens. In conclusion, our data add new evidence that neuroadaptations on TH may mediate relapse to drug-seeking behavior induced by stress within adolescence. (C) 2010 Elsevier Inc. All rights reserved.