Heterogeneous Copper‐Catalyzed Cascade Three‐Component Reaction of Amines, Carbon Disulfide and 2‐Iodoanilines Leading to 2‐Aminobenzothiazoles
Heterogeneous Copper‐Catalyzed Cascade Three‐Component Reaction of Amines, Carbon Disulfide and 2‐Iodoanilines Leading to 2‐Aminobenzothiazoles
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DOI：
10.1002/adsc.201400381
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发表时间：
2014-10
影响因子：
5.4
通讯作者：
Hong Zhao;Wen He;Ruiya Yao;Mingzhong Cai
中科院分区：
文献类型：
--
作者：
Hong Zhao;Wen He;Ruiya Yao;Mingzhong Cai
在二甲基甲酰胺（DMF）中，110 °C下，3-（2-氨乙基氨基）丙基官能化的MCM-41-固定化铜配合物[MCM-41 - 2N-CuCl]存在下，以碳酸钾（K2 CO 3）为碱，实现了胺、二硫化碳（CS2）和2-碘苯胺的非均相级联三组分反应，以良好至优异的产率得到了各种2-氨基苯并噻唑。 这种多相铜催化剂影响反应的选择性，并且可以通过简单过滤反应溶液来回收和再循环，并且用于至少10次连续试验而活性没有任何降低。
The heterogeneous cascade three‐component reaction of amines, carbon disulfide (CS2) and 2‐iodoanilines was achieved in dimethylformamide (DMF) at 110 °C in the presence of 10 mol% of 3‐(2‐aminoethylamino)propyl‐functionalized MCM‐41‐immobilized copper complex [MCM‐41‐2N‐CuCl] using potassium carbonate (K2CO3) as base, yielding a variety of 2‐aminobenzothiazoles in good to excellent yields. This heterogeneous copper catalyst influences the selectivity of the reaction and can be recovered and recycled by a simple filtration of the reaction solution and used for at least 10 consecutive trials without any decreases in activity.