Hormonal control of intestinal Fc receptor gene expression and immunoglobulin transport in suckling rats.
Hormonal control of intestinal Fc receptor gene expression and immunoglobulin transport in suckling rats.
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乳鼠肠道 Fc 受体基因表达和免疫球蛋白转运的激素控制。
DOI：
10.1172/jci116528
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Walsh,JH
中科院分区：
文献类型：
--
作者：
Martín,MG;Wu,SV;Walsh,JH
在大鼠中研究了免疫球蛋白（IG）吸收和肠道Fc受体mRNA表达的激素控制，以评估其在正常哺乳后抑制该转运系统中的潜在作用。皮质酮和L-甲状腺素治疗引起过早抑制口服给药的鼠单克隆抗体的吸收和Fc受体mRNA表达的剂量和时间依赖性的方式。低剂量皮质酮对3 d后Fc受体mRNA合成无影响，但7 d后IG转运减少5倍。高剂量皮质酮导致3 d后Fc受体减少3倍，7 d后转运和Fc受体转录水平几乎完全抑制（> 30倍）。同样，7天的高剂量甲状腺素降低血清IG转运和Fc受体（> 30倍）。然而，肾上腺切除术并不能阻止正常的哺乳后IG运输或受体合成的下降。本研究表明，外源性皮质类固醇和甲状腺激素抑制IG运输和稳态十二指肠Fc受体mRNA水平在乳鼠。然而，内源性肾上腺皮质类固醇似乎并不完全负责这个运输系统的年龄依赖性下降。图片
Hormonal control of immunoglobulin (Ig) absorption and of intestinal Fc receptor mRNA expression were investigated in rats to assess its potential role in the normal postsuckling inhibition of this transport system. Corticosterone and L-thyroxine therapy caused premature inhibition of the absorption of orally administered murine monoclonal antibody and of Fc receptor mRNA expression in a dose- and time-dependent manner. Low-dose corticosterone had no effect on Fc receptor mRNA synthesis after 3 d but decreased Ig transport fivefold after 7 d. High dose corticosterone resulted in a threefold reduction in Fc receptor after 3 d, and there was almost complete inhibition (> 30-fold) of transport and of Fc receptor transcript levels after 7 d. Similarly, 7 d of high-dose thyroxine decreased both serum Ig transport and Fc receptor (> 30-fold). However, adrenalectomy did not prevent the normal post-suckling declines in Ig transport or receptor synthesis. This study demonstrates that exogenous corticosteroids and thyroxine hormone inhibit Ig transport and steady-state duodenal Fc receptor mRNA levels in suckling rats. Endogenous adrenal steroids however, do not appear to be entirely responsible for the age-dependent decline in this transport system.Images