Chitosan-based hydrogels: Preparation, properties and applications
Chitosan-based hydrogels: Preparation, properties and applications
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DOI：
10.1016/j.ijbiomac.2018.04.034
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发表时间：
2018-08-01
影响因子：
8.2
通讯作者：
Jalali, Azin Mazloom
中科院分区：
文献类型：
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作者：
Shariatinia, Zahra;Jalali, Azin Mazloom
壳聚糖（CS）是仅次于纤维素的第二大天然多糖，具有良好的生物相容性、无毒性和可生物降解性。CS在人体内分解为无害的产物（氨基糖）。水凝胶是具有三维网络的聚合物材料，在其结构内保留大量的水，这在生物医学/环境应用中具有极大的兴趣。通常，可注射水凝胶具有对pH、温度或辐射刺激敏感的官能团。可注射支架可以通过刺激响应效应原位形成，并且它们可以克服传统支架需要手术才能放置在所需组织上的缺点。本文将介绍壳聚糖基水凝胶的抗菌/抗真菌活性及其在药物控释系统、组织工程、可注射水凝胶的制备和水处理（去除重/有毒金属和染料）中的应用。此外，对基于壳聚糖（CS）、聚乳酸（PLA）和聚乙二醇（PEG）的三种二氧化硅填充的聚合物纳米复合材料递送抗癌药物苯丁酸氮芥（CB）进行了分子动力学（MD）模拟，并说明在三种药物递送系统（DDS）中，CS纳米复合材料是最有效的DDS，这是因为对于CS系统测量到最低的药物扩散，其可以导致最持续/受控的药物递送。(C)2018 Elsevier B. V.版权所有。
Chitosan (CS), the second most plentiful natural polysaccharide next to cellulose, has valuable characteristics including biocompatibility, nontoxicity and biodegradability. CS is broken down in the human body to innocuous products (amino sugars). Hydrogels are polymeric materials with three dimensional networks retaining a huge quantity of water within their structures which are of great interest in biomedical/environmental applications. Usually, injectable hydrogels have functional groups which are sensitive to pH, temperature or irradiation stimuli. Injectable scaffolds can be formed in situ through stimuli-responsive effect and they can overcome the drawback of traditional scaffolds which require surgery in order to be placed on the desired tissue. The antibacterial/antifungal activities of chitosan-based hydrogels and their applications in controlled drug delivery/release systems, tissue engineering, preparation of injectable hydrogels and water treatment (removal of heavy/toxic metals and dyes) will be described. Moreover, the molecular dynamics (MD) simulation were performed on the delivery of the anticancer chlorambucil (CB) drug using three silica filled polymeric nanocomposites based on chitosan (CS), polylactic acid (PLA) and polyethylene glycol (PEG) and it was illustrated that among three drug delivery systems (DDSs), the CS nanocomposite was the most efficient DDS due to the lowest drug diffusion was measured for the CS system that could lead to the most sustained/controlled drug delivery. (C) 2018 Elsevier B.V. All rights reserved.