Limbal stem cell transplantation in chronic inflammatory eye disease
Limbal stem cell transplantation in chronic inflammatory eye disease
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DOI：
10.1016/s0161-6420(02)00994-6
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发表时间：
2002-05-01
期刊：
影响因子：
13.7
通讯作者：
Foster, CS
中科院分区：
文献类型：
--
作者：
Samson, CM;Nduaguba, C;Foster, CS
目的：本研究的目的是描述角膜缘干细胞移植（LSCT）治疗由潜在慢性炎症性眼病引起的严重眼表疾病患者的结果。设计：回顾性非比较性病例系列研究。参与者：9例因潜在眼部炎症性疾病引起的角膜缘干细胞缺乏而接受LSCT的患者。方法：作者回顾了9例免疫介导的眼表疾病患者的11只眼接受LSCT的记录。主要结果指标：主要结果指标为角膜表面上皮再生、角膜表面恢复和视力改善。共有11只眼睛接受自体（n = 1）或HLA匹配的活体亲属供体（n 10）LSCT治疗继发于炎症性疾病的眼表疾病。10只眼（91%）术后即刻角膜表面上皮再生，平均10天（范围，3-21天）。6眼（55%）角膜表面获得长期恢复，6眼（55%）视力提高。不良结局的原因包括微生物感染、角膜缘干细胞移植排斥和角膜溃疡。无供体眼有并发症。结论：患者与潜在的免疫介导的疾病，如Stevens-Johnson综合征，中毒性表皮坏死松解症，或眼瘢痕性类天疱疮，谁接受LSCT的成功率较低，比那些非炎性眼表疾病的患者。眼科学2002;109：862-868（C）2002，美国眼科学会。
Objective: The goal of this study was to describe the outcome of limbal stem cell transplantation (LSCT) in patients with severe ocular surface disease caused by underlying chronic inflammatory eye disease.Design: Retrospective noncomparative case series.Participants: Nine patients with limbal stem cell deficiency caused by an underlying ocular inflammatory disease who underwent LSCT.Methods: The authors reviewed the records of 11 eyes of 9 patients with immunologically mediated ocular surface disease that underwent LSCT.Main Outcome Measures: The main outcome measures were reepithelialization of the corneal surface, restoration of corneal surface, and improvement in visual acuity.Results: A total of 11 eyes underwent either autologous (n = 1) or HLA-matched living related donor (n 10) LSCT for ocular surface disease secondary to inflammatory disease. Reepithelialization of the corneal surface in the immediate postoperative period occurred in 10 eyes (91%) within an average of 10 days (range, 3-21 days). Long-term restoration of the corneal surface was achieved in six (55%) eyes, Visual acuity improved in six eyes (55%). Reasons for poor outcomes included microbial infection, limbal stem cell graft rejection, and corneal ulceration. No donor eyes had complications.Conclusions: Patients with underlying immunologically mediated diseases, such as Stevens-Johnson syndrome, toxic epidermal necrolysis, or ocular cicatricial pemphigoid, who undergo LSCT have lower success rates than do those patients with noninflammatory ocular surface diseases. Ophthalmology 2002;109:862-868 (C) 2002 by the American Academy of Ophthalmology.