Clinicopathologic Characteristics and Prognosis of Gastric Cancer Invading the Subserosa
Clinicopathologic Characteristics and Prognosis of Gastric Cancer Invading the Subserosa
复制标题
侵犯浆膜下层的胃癌的临床病理特征及预后
DOI：
10.1002/jso.21678
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发表时间：
2010-12-01
影响因子：
2.5
通讯作者：
Xu, Hui-Mian
中科院分区：
文献类型：
--
作者：
Jiang, Cheng-Gang;Wang, Zhen-Ning;Xu, Hui-Mian
背景：胃癌侵犯浆膜下层（SS）的临床病理特征和预后尚不清楚。方法：回顾性分析1980年至2001年行胃切除术的1201例进展期胃癌（pT2、pT3和pT4a）患者的临床病理特征和预后，并将侵犯SS的胃癌的临床病理特征和预后与侵入浆膜下层的胃癌的临床病理特征和预后进行比较。 结果：与侵犯固有肌层（MP）和浆膜层（Se）的癌症相比，侵犯固有肌层（MP）和浆膜层（Se）的癌症患者肿瘤更大，淋巴管侵犯、淋巴结和腹膜转移更频繁。然而，与侵入硒的癌症相比，他们的肿瘤较小，淋巴管侵犯、淋巴结和腹膜转移也较少。在 pN0、pN1、pN2 和 pN3 阶段，侵入 SS 的癌症的术后生存率介于侵入 MP 和 Se 的癌症之间。多因素分析显示淋巴结转移、切除方式、治愈率、腹膜转移、肝转移是侵袭SS的胃癌患者的独立预后因素。结论：侵袭SS的胃癌临床病理特征和预后介于侵袭MP和Se的胃癌之间。 J.外科医生。安科尔。 2010；102：737-741。 (C) 2010 Wiley-Liss, Inc.
Background: The clinicopathologic characteristics and prognosis for gastric cancer invading subserosa (SS) are still not clear.Methods: A retrospective analysis was under taken of 1,201 patients with advanced gastric cancer (pT2, pT3, and pT4a) who had undergone gastrectomy from 1980 to 2001. Clinicopathologic characteristics and prognosis of gastric cancer invading SS were compared with those of cancers invading muscularis propria (MP) and serosa (Se).Results: Patients with cancers invading SS had larger tumors and more frequent lymphovascular invasion, lymph node and peritoneal metastasis than those with cancers invading MP. Yet, they had smaller tumors and less frequent lymphovascular invasion, lymph node and peritoneal metastasis than those with cancers invading Se. Postoperative survival with cancers invading SS was intermediate between that with cancers invading MP and Se at pN0, pN1, pN2, and pN3 stages. Multivariate analysis indicated lymph node metastasis, type of resection, curability, peritoneal metastasis, and hepatic metastasis were independent prognostic factors for patients with cancers invading SS.Conclusions: Clinicopathologic characteristics and prognosis of gastric cancer invading SS are intermediate between those of gastric cancers invading MP and Se. J. Surg. Oncol. 2010;102:737-741. (C) 2010 Wiley-Liss, Inc.