Mechanisms for the prevention of vitamin E excess.
Mechanisms for the prevention of vitamin E excess.
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DOI：
10.1194/jlr.r032946
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发表时间：
2013-09-01
影响因子：
6.5
通讯作者：
Traber, Maret G
中科院分区：
文献类型：
--
作者：
Traber, Maret G
肝脏是调节脂蛋白摄取、合成和分泌的枢纽，是通过细胞色素P450氧化系统（I期）、结合系统（II期）和转运蛋白（III期）进行异生物质解毒的场所。这两个主要的肝脏系统控制维生素E的状态。相对于八种天然存在的维生素E形式，α-生育酚的偏好机制在很大程度上取决于肝脏，并且包括α-生育酚从肝脏优先分泌到血浆中，用于其在循环脂蛋白中的运输，用于随后被组织摄取，以及非α-生育酚形式的优先肝脏代谢。这些机制是本次审查的重点。
The liver is at the nexus of the regulation of lipoprotein uptake, synthesis, and secretion, and it is the site of xenobiotic detoxification by cytochrome P450 oxidation systems (phase I), conjugation systems (phase II), and transporters (phase III). These two major liver systems control vitamin E status. The mechanisms for the preference for alpha-tocopherol relative to the eight naturally occurring vitamin E forms largely depend upon the liver and include both a preferential secretion of alpha-tocopherol from the liver into the plasma for its transport in circulating lipoproteins for subsequent uptake by tissues, as well as the preferential hepatic metabolism of non-alpha-tocopherol forms. These mechanisms are the focus of this review.