Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition
Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition
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DOI：
10.1086/315127
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发表时间：
1999-12-01
影响因子：
6.4
通讯作者：
Kreiss, J
中科院分区：
文献类型：
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作者：
Martin, HL;Richardson, BA;Kreiss, J
在肯尼亚蒙巴萨的性工作者人群中，进行了一项前瞻性队列研究，以检查阴道定植乳酸菌、细菌性阴道病（BV）、获得人类免疫缺陷病毒1型（HIV-1）和性传播疾病之间的关系。总共招募了657名HIV-1血清阴性妇女，并每月随访一次。在基线时，只有26%的女性被乳酸菌定植。在随访期间，在单独的多变量模型中控制其他确定的危险因素后，阴道培养乳酸菌的缺失与获得HIV-1感染的风险增加相关（风险比[HR]， 2.0； 95%置信区间[CI]， 1.2-3.5）和淋病（风险比，1.7;95% CI, 1.1-2.6）。阴道革兰氏染色上异常菌群的存在与HIV-1获得（HR, 1.9; 95% CI, 1.1-3.1）和毛滴虫感染（HR, 1.8; 95% CI, 1.3-2.4）的风险增加有关，应评估治疗细菌性阴道炎和促进阴道定植乳酸菌作为降低女性风险的潜在干预措施。感染HIV-1、淋病和滴虫病的可能性。
A prospective cohort study was conducted to examine the relationship between vaginal colonization with lactobacilli, bacterial vaginosis (BV), and acquisition of human immunodeficiency virus type 1 (HIV-1) and sexually transmitted diseases in a population of sex workers in Mombasa, Kenya, In total, 657 HIV-l-seronegative women were enrolled and followed at monthly intervals. At baseline, only 26% of women were colonized with Lactobacillus species. During follow-up, absence of vaginal lactobacilli on culture was associated with an increased risk of acquiring HIV-1 infection (hazard ratio [HR], 2.0; 95% confidence interval [CI], 1.2-3.5) and gonorrhea (HR, 1.7; 95% CI, 1.1-2.6), after controlling for other identified risk factors in separate multivariate models. Presence of abnormal vaginal flora on Gram's stain was associated with increased risk of both HIV-1 acquisition (HR, 1.9; 95% CI, 1.1-3.1) and Trichomonas infection (HR, 1.8; 95% CI, 1.3-2.4), Treatment of BV and promotion of vaginal colonization with lactobacilli should be evaluated as potential interventions to reduce a woman's risk. of acquiring HIV-1, gonorrhea, and trichomoniasis.