Dynamic analysis of oral Candida carriage, distribution, and antifungal susceptibility in HIV-infected patients during the first year of highly active antiretroviral therapy in Guangxi, China
Dynamic analysis of oral Candida carriage, distribution, and antifungal susceptibility in HIV-infected patients during the first year of highly active antiretroviral therapy in Guangxi, China
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中国广西HIV感染者高效抗逆转录病毒治疗第一年口腔念珠菌携带、分布和抗真菌药物敏感性的动态分析
DOI：
10.1111/jop.12192
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发表时间：
2014-10-01
影响因子：
3.3
通讯作者：
Tao, Renchuan
中科院分区：
文献类型：
--
作者：
Jiang, Lanlan;Yong, Xiangzhi;Tao, Renchuan
研究背景高效抗逆转录病毒治疗（HAART）作为HIV/AIDS患者免疫重建的有效治疗手段，可能对口腔念珠菌感染状况产生影响。我们调查了口腔念珠菌携带，分布，和抗真菌药物的敏感性动态HAART的第一年在成人HIV感染者在广西，Chinese. MethodsForty五个成年HIV感染者谁收到了他们的第一年HAART在艾滋病门诊广西疾病控制中心（CDC）和31名健康人被招募。获得临床信息和口腔检查。分别在基线、HAART治疗3、6、12个月时采集患者的口腔冲洗液进行培养，并按照标准微生物学技术鉴定念珠菌属。结果45例HIV/AIDS患者在HAART治疗的第1年内，口腔念珠菌的载量逐渐下降（P
BackgroundHighly active antiretroviral therapy (HAART) as an effective therapy for immune reconstruction among patients with HIV/AIDS might have influence on oral Candida status. We investigated oral Candida carriage, distribution, and antifungal susceptibility dynamically during the first year of HAART among adult HIV-infected patients in Guangxi, China.MethodsForty-five adult HIV-infected patients who received their first year HAART in the AIDS clinic of the Guangxi Center for Disease Control (CDC) and 31 healthy individuals were recruited. Clinical information and oral examinations were obtained. Oral rinses taken from patients at baseline, 3, 6, 12months during HAART, respectively, were cultured, and Candida species were identified following standard microbiological techniques. In vitro antifungal susceptibilities were tested by the broth microdilution method.ResultsThe oral Candida load decreased gradually in the 45 patients with HIV/AIDS during the first year of HAART (P