Passive flow switching valves on a centrifugal microfluidic platform
Passive flow switching valves on a centrifugal microfluidic platform
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DOI：
10.1016/j.snb.2007.07.079
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发表时间：
2008-01-15
影响因子：
8.4
通讯作者：
Madou, Marc J.
中科院分区：
文献类型：
--
作者：
Kim, Jitae;Kido, Horacio;Madou, Marc J.
在本文中，我们提出了两种不同的方法，用于在离心微流体平台上的被动流量切换阀，其控制在公共入口和两个出口通道相遇的接合处的流动液体的方向。流动的切换可以通过依赖于科里奥利力来执行，科里奥利力改变其指向方向，垂直于流动方向，具有在对称接合处的双层布置中的盘的旋转方向，或者通过在非对称接合处的两种流体之间捕获的气穴的流体电容来执行。当与基于亲和力的分离技术（例如，将DNA吸附在二氧化硅基质上，然后洗脱），在需要提取特定目标生物分子的快速生物测定和生物医学诊断应用中具有巨大的潜力。(C)2007年由Elsevier B.V.出版。
In this paper we present two different methods for a passive flow switching valve on a centrifugal microfluidic platform, which controls the direction of a flowing liquid at a junction where a common inlet and two outlet channels meet. Switching of the flow can be performed either by relying on the Coriolis force that changes its pointing direction, perpendicular to the flow direction, with the rotational direction of a disk in a double layered arrangement at a symmetrical junction, or by means of the fluidic capacitance of an air pocket trapped between two fluids at a non-symmetric junction. This flow-switching valve, when combined with affinity-based separation techniques (e.g., adsorption of DNA on a silica matrix, followed by elution), has great potential in rapid bioassays and biomedical diagnostic applications that require the extraction of specific target biomoleclues. (C) 2007 Published by Elsevier B.V.