ERYTHROPHAGOCYTIC T-GAMMA LYMPHOMA - A CLINICOPATHOLOGIC ENTITY RESEMBLING MALIGNANT HISTIOCYTOSIS
ERYTHROPHAGOCYTIC T-GAMMA LYMPHOMA - A CLINICOPATHOLOGIC ENTITY RESEMBLING MALIGNANT HISTIOCYTOSIS
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DOI：
10.1056/nejm198103123041106
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发表时间：
1981-01-01
影响因子：
158.5
通讯作者：
LAMBERG, J
中科院分区：
文献类型：
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作者：
KADIN, ME;KAMOUN, M;LAMBERG, J
临床病理学研究表明，T细胞淋巴瘤在临床表现、病程和形态学上是异质性的。蕈样肉芽肿和Sézary综合征主要累及皮肤，呈缓慢进展，特征为外周T细胞脑形核浸润表皮。1 T细胞淋巴母细胞性淋巴瘤通常表现为纵隔肿块，通常扩散至骨髓和中枢神经系统，并迅速致命。2，3具有独特临床和病理特征的T细胞淋巴瘤的其他变体已被描述。4，5我们报告一个独特的T细胞淋巴瘤在两个成人患者的临床和病理特征类似的恶性肿瘤。
CLINICOPATHOLOGICAL studies suggest that the T-cell lymphomas are heterogeneous with respect to clinical presentation, course, and morphology. Mycosis fungoides and the Sézary syndrome affect the skin primarily, are slowly progressive, and are characterized by peripheral T cells with cerebriform nuclei that infiltrate the epidermis.1T-cell lymphoblastic lymphoma often presents as a mediastinal mass, commonly spreads to the bone marrow and central nervous system, and is rapidly fatal.2,3Other variants of T-cell lymphoma with distinctive clinical and pathologic features have been described.4,5We report a unique T-cell lymphoma in two adult patients with clinical and pathological features resembling those of malignant . . .