Plasma Carotenoids Are Inversely Associated With Dementia Risk in an Elderly French Cohort
Plasma Carotenoids Are Inversely Associated With Dementia Risk in an Elderly French Cohort
复制标题
DOI：
10.1093/gerona/glv135
复制
发表时间：
2016-05-01
影响因子：
5.1
通讯作者：
Barberger-Gateau, Pascale
中科院分区：
文献类型：
--
作者：
Feart, Catherine;Letenneur, Luc;Barberger-Gateau, Pascale
背景：尽管水果和蔬菜的摄入与痴呆症风险的降低有关，但缺乏关于这种联系背后的营养物质的研究。我们的目标是分析血浆类胡萝卜素与法国老年社区居民患痴呆症和阿尔茨海默病(AD)的风险的关系。方法：研究人群包括1092名非痴呆老年参与者，来自波尔多-三城队列，跟踪时间长达10年(范围：1.8-10.8年，中位数：9.5年)。神经学家委员会对痴呆症和阿尔茨海默病进行了诊断。基线时测定血浆类胡萝卜素(β-胡萝卜素、α-胡萝卜素、番茄红素、叶黄素、玉米黄质和β-隐黄质)的浓度。每种血浆类胡萝卜素(粗胡萝卜素或表示为与血脂的比率(总胆固醇+甘油三酯))与痴呆或阿尔茨海默病的风险之间的关系采用多变量COX模型进行纵向分析。结果：在随访期间，199例痴呆患者，包括132例阿尔茨海默病。在对社会人口学数据、饮食质量和临床变量(包括基线认知表现)进行调整后，只有较高的叶黄素浓度(被认为是血脂的函数)与降低全因痴呆症和AD的风险一致地显著相关(风险比=0.808，95%可信区间=0.671-0.973，p=0.024和风险比=0.759，95%可信区间=0.600-0.960，p=0.021，结论：这一大群老年参与者表明，保持较高的叶黄素浓度相对于血脂可能适度降低痴呆症和AD的风险。
Background: Although intake of fruits and vegetables has been associated with a decreased risk of dementia, studies focusing on nutrients underlying this association are lacking. Our objective was to analyze the relation between plasma carotenoids and the risk of dementia and Alzheimer's disease (AD) in French elderly community dwellers.Methods: The study population consisted of 1,092 nondemented older participants, from the Three-City-Bordeaux cohort followed for up to 10 years (range: 1.8-10.8 years, median: 9.5 years). Dementia and AD were diagnosed by a committee of neurologists. The concentration of plasma carotenoids (beta-carotene, alpha-carotene, lycopene, lutein, zeaxanthin, and beta-cryptoxanthin) was determined at baseline. Longitudinal analyses of the association between each plasma carotenoid, either crude or expressed as a ratio to plasma lipids (total cholesterol + triglycerides), and the risk of dementia or AD were performed by multivariate Cox models.Results: During follow-up, 199 dementia cases, including 132 AD, occurred. After adjustment for sociodemographic data, diet quality, and clinical variables, including baseline cognitive performances, only higher lutein concentration, considered as a function of plasma lipids, was consistently significantly associated with a decreased risk of all-cause dementia and AD (hazard ratio = 0.808, 95% confidence interval = 0.671-0.973, p = .024 and hazard ratio = 0.759, 95% confidence interval = 0.600-0.960, p = .021, respectively for + 1 SD).Conclusion: This large cohort of older participants suggests that maintaining higher concentrations of lutein in respect to plasma lipids may moderately decrease the risk of dementia and AD.