Schistosoma haematobium infection and morbidity before and after large-scale administration of praziquantel in Burkina Faso
Schistosoma haematobium infection and morbidity before and after large-scale administration of praziquantel in Burkina Faso
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DOI：
10.1086/520515
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发表时间：
2007-09-01
影响因子：
6.4
通讯作者：
Webster, Joanne P.
中科院分区：
文献类型：
--
作者：
Koukounari, Artemis;Gabrielli, Albis F.;Webster, Joanne P.
背景资料。在撒哈拉以南非洲，有1.12亿人感染血吸虫，感染最严重的是5-15岁的儿童。我们描述了一项纵向流行病学研究，评估了大规模使用吡喹酮治疗血吸虫病和阿苯达唑治疗土源性蠕虫前后儿童血吸虫感染和相关发病率的关系。在基线时，贫血和/或严重微量血尿的儿童中观察到较高的血结核杆菌感染强度，但营养不良的风险与血结核杆菌感染强度之间没有明显的关联。然而，在治疗1年后，观察到血瘤链球菌感染的患病率和强度显著降低。从驱虫药治疗提高血红蛋白浓度方面受益最大的儿童是那些在基线水平有贫血和在基线水平有高度阳性微量血尿的儿童。这项研究表明，即使是一轮大规模化疗也可以对儿童的血吸虫感染及其相关发病率产生重大影响。
Background. In sub-Saharan Africa, 112 million people are infected with Schistosoma haematobium, with the most intense infections in children 5-15 years old.Methods. We describe a longitudinal epidemiological study that evaluates the relationship between S. haematobium infection and associated morbidity in children before and after the large-scale administration of praziquantel for schistosomiasis and albendazole for soil-transmitted helminths.Results. At baseline, higher intensities of S. haematobium infection were observed in children with anemia and/or severe microhematuria, but there was no apparent association between the risk of undernutrition and intensity of S. haematobium infection. Significant reductions in the prevalence and intensity of S. haematobium infection 1 year after treatment were, however, observed. Children who benefited the most from anthelmintic treatment in terms of increased hemoglobin concentrations were those who had anemia at baseline and those with highly positive microhematuria scores at baseline.Conclusions. This study suggests that even a single round of mass chemotherapy can have a substantial impact on S. haematobium infection and its associated morbidity in children.