Carbohydrate tolerance and insulin receptor binding in children with hypopituitarism: response after acute and chronic human growth hormone administration.
Carbohydrate tolerance and insulin receptor binding in children with hypopituitarism: response after acute and chronic human growth hormone administration.
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垂体功能减退症儿童的碳水化合物耐受性和胰岛素受体结合：急性和慢性人类生长激素给药后的反应。
DOI：
10.1210/jcem-53-3-507
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
M. Scott
中科院分区：
文献类型：
--
作者：
B. Lippe;S. Kaplan;M. Golden;S. Hendricks;M. Scott
我们研究了一组GH缺乏儿童在短期（急性）和长期（慢性）人类GH （hGH）治疗前后对标准口服葡萄糖耐量试验（OGTT）和静脉胰岛素耐量试验（IVITT）的碳水化合物耐量反应。在每个治疗阶段评估红细胞和单核细胞胰岛素受体结合情况。在未治疗状态下，与对照组相比，OGTT反应显示基础低胰岛素血症和胰岛素分泌减少。然而，葡萄糖反应仅略高于对照组。IVITT提示胰岛素敏感性增强。然而，我们无法证明红细胞或单核细胞胰岛素受体结合的显著差异来解释这些发现。慢性hGH给药后，口服葡萄糖摄入后胰岛素分泌增加，但葡萄糖耐量受损，而对外源性胰岛素的敏感性不变。胰岛素结合的改变似乎与…
We investigated carbohydrate tolerance in response to a standard oral glucose tolerance test (OGTT) and an iv insulin tolerance test (IVITT) in a group of GH-deficient children before and after short term (acute) and prolonged (chronic) human GH (hGH) administration. Erythrocyte and monocyte insulin receptor binding were assessed during each treatment phase. In the untreated state, OGTT responses demonstrated basal hypoinsulinemia and diminished insulin secretion compared to controls. Glucose responses, however, were only slightly greater than the controls. IVITT suggested enhanced insulin sensitivity. However, we were unable to demonstrate significant differences in either erythrocyte or monocyte insulin receptor binding to account for these findings. After chronic hGH administration, insulin secretion increased following oral glucose ingestion, but glucose tolerance was impaired, while the sensitivity to exogenous insulin was unchanged. Alterations in insulin binding did not appear to be associated with...
生长调节素-C 与胰岛素样生长因子-I 共享羧基末端抗原决定簇。
DOI：
10.1210/jcem-51-3-672
发表时间：
1980
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Hintz,RL;Rinderknecht,E
通讯作者：
Rinderknecht,E