Impact of HIV-AIDS on tuberculosis treatment outcome in Southern Ethiopia - A retrospective cohort study.
Impact of HIV-AIDS on tuberculosis treatment outcome in Southern Ethiopia - A retrospective cohort study.
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DOI：
10.1016/j.jctube.2021.100279
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发表时间：
2021-12
影响因子：
2
通讯作者：
Abiye T
中科院分区：
文献类型：
--
作者：
Alayu Alemu M;Yesuf A;Girma F;Adugna F;Melak K;Biru M;Seyoum M;Abiye T
在全球范围内，与 HIV 阴性结核病患者相比，HIV 阳性结核病患者的结核病治疗成功率较差。本研究旨在确定艾滋病毒/艾滋病的影响以及与结核病治疗结果相关的因素。这项研究是对和散那镇四个公共卫生机构五年结核病数据的回顾性队列研究。采用系统随机抽样技术，总共纳入了 604 名研究参与者。对比率、比率和比例进行了描述性分析，还进行了二元逻辑回归、双变量和多变量分析。共有 604 名结核病患者参加了这项研究。 302 人（50%）同时感染 HIV。总体治疗成功率为90.1%（544/604）。 TB-HIV 合并感染患者的治疗成功率为 86.4% (261/302)，非合并感染患者的治疗成功率为 93.7% (283/302)。 TB-HIV 合并感染患者治疗结果不成功的风险较高（调整相对风险 [ARR]：2.7；95% 置信区间 [CI]：1.4 – 5.2）。农村居民（ARR：3.3；CI：1.4 – 5.0）、再治疗类别患者（ARR：2.7；CI：1.4 – 5.1）和慢性病患者（ARR：3.3；CI：1.3 – 8.1）治疗结果不成功的风险也较高。与世界卫生组织的最低要求相比，结核病治疗成功率较高。 HIV感染者、农村居民、复治患者和慢性病患者的治疗成功率较低。因此，应适当重视这些高危人群。
Globally, the Tuberculosis treatment success rate was worse for HIV-positive TB patients compared with HIV- negative TB patients. This study aimed at determining the impact of HIV-AIDS and factors associated with TB treatment outcomes. This study was a retrospective cohort study of five years of tuberculosis data from four public health facilities in Hosanna Town. A total of 604 study participants were included using a systematic random sampling technique. Descriptive analysis of ratios, rates, and proportions was done and binary logistic regression, bivariable and multivariable, analysis was also done. A total of 604 TB patients were enrolled in this study. 302 (50%) were HIV co-infected. The overall treatment success rate was 90.1% (544/604). Treatment success rates are 86.4% (261/302) for TB-HIV co-infected patients and 93.7% (283/302) for non-co-infected patients. TB-HIV co-infected patients had a higher risk of an unsuccessful treatment outcome (Adjusted Relative Risk [ARR]: 2.7; 95% Confidence Interval [CI]: 1.4 – 5.2). The risk of unsuccessful treatment outcome is also higher among rural residents (ARR: 3.3; CI: 1.4 – 5.0), patients on the re-treatment category (ARR: 2.7; CI: 1.4 – 5.1), and with chronic disease (ARR: 3.3; CI: 1.3 – 8.1). TB treatment success rate is good as compared to the WHO minimum requirement. Successful treatment outcome is lower among patients with HIV infection, rural residents, patients on re-treatment, and patients with chronic disease. Therefore, due emphasis should be given to these high-risk groups.
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影响因子：
1.2
作者：
Abebe, Gemeda;Bonsa, Zegeye;Kebede, Wakjira
通讯作者：
Kebede, Wakjira
影响因子：
2.3
作者：
Kefale, Adane Teshome;Anagaw, Yeniewa Kerie
通讯作者：
Anagaw, Yeniewa Kerie
影响因子：
4.8
作者：
Adamu, Aishatu Lawal;Aliyu, Muktar H.;Abubakar, Ibrahim
通讯作者：
Abubakar, Ibrahim
影响因子：
3.1
作者：
Adane K;Spigt M;Dinant GJ
通讯作者：
Dinant GJ
影响因子：
3.9
作者：
Tafess K;Beyen TK;Abera A;Tasew G;Mekit S;Sisay S;Tadesse L;Siu GKH
通讯作者：
Siu GKH