Hepatitis B virus infection and intrahepatic cholangiocarcinoma in Korea: A case-control study
Hepatitis B virus infection and intrahepatic cholangiocarcinoma in Korea: A case-control study
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DOI：
10.1111/j.1572-0241.2008.01796.x
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发表时间：
2008-07-01
影响因子：
9.8
通讯作者：
Suh, Dong J.
中科院分区：
文献类型：
--
作者：
Lee, Tae Y.;Lee, Sang S.;Suh, Dong J.
目的：不同人群中肝内胆管癌（ICC）的风险因素存在很大差异。一些研究表明，丙型肝炎病毒（HCV）感染可能在ICC的发展中发挥作用，而B型肝炎病毒（HBV）感染的作用尚不清楚。为了确定HBV或HCV感染是否是ICC的危险因素，我们比较了2000年至2004年间诊断为组织学确诊的ICC的622例患者的基线人口统计学和临床因素，结果：HBV感染（OR = 2.3，95% CI = 1.6-3.3）与ICC的发生有显著相关性，而HCV感染与ICC的发生无显著相关性。ICC的其他重要危险因素包括肝硬化（OR 13.6），重度饮酒（OR 6.6），糖尿病（OR 3.2），华支睾吸虫感染（OR 13.6），肝内胆管结石（OR 50.0）和胆总管囊肿（或10.7）结论：我们的研究结果表明，ICC的发展似乎是更密切相关的HBV感染比HCV感染在韩国，HBV和ICC的地方病。
OBJECTIVES: There is a wide variation in risk factors for intrahepatic cholangiocarcinoma (ICC) among various populations. Several studies have suggested that hepatitis C virus (HCV) infection may play a role in the development of ICC, whereas the role of hepatitis B virus (HBV) infection is less clear.METHODS: To determine whether HBV or HCV infection is a risk factor of ICC, we compared baseline demographic and clinical factors in 622 patients diagnosed between 2000 and 2004 with histologically confirmed ICC and 2,488 healthy controls, matched 4:1 with ICC patients for sex and year of birth.RESULTS: HBV infection (odds ratio [OR] 2.3, 95% confidence interval [CI] 1.6-3.3), but not HCV infection, was significantly related to ICC. Other significant risk factors for ICC included liver cirrhosis (OR 13.6), heavy alcohol consumption (OR 6.6), diabetes (OR 3.2), Clonorchis sinensis infection (OR 13.6), hepatolithiasis (OR 50.0), and choledochal cysts (OR 10.7).CONCLUSIONS: Our results indicate that development of ICC seems to be more closely related to HBV infection than to HCV infection in Korea, where both HBV and ICC are endemic.