Combination of microwave reactions with fluorous separations in the palladium-catalyzed synthesis of aryl sulfides.
Combination of microwave reactions with fluorous separations in the palladium-catalyzed synthesis of aryl sulfides.
复制标题
钯催化芳基硫醚合成中微波反应与氟分离的结合。
DOI：
10.1023/b:modi.0000006825.12186.5f
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发表时间：
2003
影响因子：
3.8
通讯作者：
Chen,ChristineHiu-Tung
中科院分区：
文献类型：
--
作者：
Zhang,Wei;Lu,Yimin;Chen,ChristineHiu-Tung
微波反应与氟分离的耦合可以显着提高高速合成的效率。本文描述了在微波辐射下通过钯催化全氟烷基磺酸芳基酯 (C8F17O2SOAr) 与硫醇 (RSH) 交叉偶联合成芳基硫醚的氟代合成方法。氟固相萃取 (F-SPE) 用于纯化反应混合物。反应和分离过程不涉及氟溶剂。氟合成进一步扩展到取代乙内酰脲和酰胺支架的多步合成。
Coupling of microwave reactions with fluorous separations can dramatically increase the efficiency of high-speed synthesis. Described in this paper is a fluorous synthesis of aryl sulfides by palladium-catalyzed cross-coupling of aryl perfluoroalkylsulfonates (C8F17O2SOAr) with thiols (RSH) under microwave irradiation. Fluorous solid-phase extractions (F-SPE) are employed for the purification of reaction mixtures. No fluorous solvents are involved in reaction and separation processes. The fluorous synthesis is further extended to the multi-step synthesis of substituted hydantoin and amide scaffolds.