The intrarenal renin-angiotensin system in hypertension.
The intrarenal renin-angiotensin system in hypertension.
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DOI：
10.1111/j.1523-1755.2004.00539.x
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发表时间：
2004-04
影响因子：
19.6
通讯作者：
L. Navar
中科院分区：
文献类型：
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作者：
L. Navar
一名患有2型糖尿病和高血压的50岁女性入住波士顿布里格姆妇女医院，进入一项涉及血管紧张素II（Ang II）受体阻滞剂血流动力学反应的临床研究方案。她在40岁时因严重头痛被送到当地急诊室。当时她的血糖超过800 mg/dL。口服降糖药治疗失败1年后，开始胰岛素治疗。她的血糖控制得很好，她抱怨每晚两次尿床。她的手和脚也有灼热和刺痛的神经病变，她患有与压力有关的偏头痛。患者的母亲和父亲均死于2型糖尿病并发症。她的五个兄弟姐妹中有一个患有糖尿病，需要口服药物治疗。病人有三个孩子，他们都很好。高血脂症和哮喘病史具有重要意义;最近一次发作是在8年前。她还有心绞痛。铊灌注显像
A 50-year-old woman with type 2 diabetes mellitus and hypertension was admitted to Brigham and Women’s Hospital in Boston for entry into a clinical research protocol involving hemodynamic responses to angiotensin II (Ang II) receptor blockade. She presented to a local emergency room with severe headache at the age of 40. Her blood glucose at that time exceeded 800 mg/dL. After 1 year of failed therapy with oral hypoglycemic agents, insulin therapy was initiated. Her blood sugar control has been fair; she complains of twice nightly nocturia. She also has a burning and tingling neuropathy in her hands and feet, and she suffers from migraines related to stress. The patient’s mother and father both died from complications of type 2 diabetes mellitus. One of her five siblings has diabetes that is treated with oral medications. The patient has three children who are well. The medical history is significant for hypertriglyceridemia and asthma; the most recent episode was 8 years ago. She also has angina. Thallium perfusion imaging was