Increased serum leptin levels and over expression of leptin receptors are associated with the invasion and progression of renal cell carcinoma
Increased serum leptin levels and over expression of leptin receptors are associated with the invasion and progression of renal cell carcinoma
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DOI：
10.1016/j.juro.2006.06.039
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发表时间：
2006-10-01
影响因子：
6.6
通讯作者：
Hayakawa, Masamichi
中科院分区：
文献类型：
--
作者：
Horiguchi, Akio;Sumitomo, Makoto;Hayakawa, Masamichi
目的：瘦素是一种脂肪细胞衍生的细胞因子，与肥胖密切相关，最近被证明与癌发生和癌症进展有关。由于肥胖是肾细胞癌的重要危险因素，我们研究了瘦素与肾细胞癌发生之间的联系。 材料和方法：对 57 例肾细胞癌患者的术前血清瘦素水平与肿瘤标本中瘦素受体表达以及各种临床病理参数之间的关系进行了分析。结果：血清瘦素水平为 1.2 至 16.2 ng/ml（平均 4.5）。在 57 个肿瘤中，有 22 个（38.6%）表现出高瘦素受体表达。有肿瘤标本静脉侵犯的患者与无肿瘤标本静脉侵犯的患者相比，血清瘦素水平显着较高（p = 0.030），而瘦素受体高表达的患者与低瘦素受体表达的患者相比，血清瘦素水平更高（p = 0.019）。高瘦素受体表达与静脉侵犯（p = 0.013）、组织学类型（p = 0.0076）和区域淋巴结转移（p = 0.047）之间存在显着相关性。在 42 名 N0M0 疾病患者中，血清瘦素水平为 5.0 ng/ml 或更高的患者的无进展生存期明显短于水平较低的患者 (p = 0.0043)。多变量Cox比例风险模型分析表明，较高的血清瘦素是无进展生存期的独立预测因子（p = 0.0406）。结论：瘦素和瘦素受体可能在肾细胞癌的侵袭中发挥关键作用，并且它们可能是有价值的进展预测因子。
Purpose: Leptin, an adipocyte derived cytokine that is closely associated with obesity, was recently shown to be involved in carcinogenesis and cancer progression. Because obesity is a significant risk factor for renal cell carcinoma, we investigated the link between leptin and the development of renal cell carcinoma.Materials and Methods: Associations between preoperative serum leptin levels and leptin receptor expression in tumor specimens and various clinicopathological parameters were analyzed in 57 patients with renal cell carcinoma.Results: Serum leptin levels were 1.2 to 16.2 ng/ml (mean 4.5). Of 57 tumors 22 (38.6%) demonstrated high leptin receptor expression. Serum leptin levels were significantly higher in patients with vs without tumor specimen venous invasion (p = 0.030) and higher in patients with high vs low leptin receptor expression (p 0.019). There were significant associations between high leptin receptor expression and the presence of venous invasion (p = 0.013), histological type (p = 0.0076) and regional lymph node metastasis (p = 0.047). Of 42 patients with N0M0 disease those with serum leptin 5.0 ng/ml or more had significantly shorter progression-free survival than patients with lower levels (p = 0.0043). Multivariate Cox proportional hazards model analysis demonstrated that higher serum leptin was an independent predictor of progression-free survival (p = 0.0406).Conclusions: Leptin and leptin receptor could have a key role in the invasion of renal cell carcinoma and they could be valuable predictors of progression.