Progress toward an ambulatory pump-lung.
Progress toward an ambulatory pump-lung.
复制标题
迈向动态泵肺的进展。
DOI：
10.1016/j.jtcvs.2005.04.032
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Griffith,BartleyP
中科院分区：
文献类型：
--
作者：
Wu,ZhongjunJ;Gartner,Mark;Litwak,KennethN;Griffith,BartleyP
目前可用于急性和慢性肺部疾病的疗法并不有效，并且具有与所使用的技术相关的各种问题。我们提出了一种新的主动混合泵肺的目标是提供总的呼吸支持门诊patients. METHODS的泵肺是基于在一个受约束的涡流主动混合氧合的概念。中空纤维膜的旋转破坏了浓度边界层，提高了气体交换效率，同时泵送血液。因此，实现足以用于总呼吸支持的气体转移所需的膜的量相当小。一系列的研究，包括计算设计，实验台测试，并在体内动物实验，已被执行到一个可行的人工泵-肺装置的概念，实现了一系列的泵-肺原型膜表面积为0.17至0.5 m2的设计和表征，在体外与牛血，表现出极高的气体交换效率。在小牛中评价了具有0.5 m2的气体交换表面积的原型。该设备提供了约115毫升/分钟的氧气输送的动物的呼吸支持长达5 day.CONCLUSIONSProgress到目前为止，表明成功的体外短期肺，可以切换和透析设备一样的可能性很高。我们的设备的独特之处在于，它集成了泵送和主动混合原理，可实现出色的气体输送，并消除了天然右心室通过人工肺和天然肺为血液提供动力的能力。
OBJECTIVESCurrently available therapies for acute and chronic lung diseases have not been effective and have various problems associated with the technologies used. We present a novel active mixing pump-lung with the goal of providing total respiratory support to ambulatory patients.METHODSThe pump-lung is based on the concept of active mixing oxygenation within a constrained vortex. The rotation of hollow-fiber membranes disrupts the concentration boundary layer, increasing gas exchange efficiency, and simultaneously pumps the blood. Consequently, the amount of membranes required to achieve gas transfer sufficient for total respiratory support is considerably small. A series of studies, including computational design, experimental bench testing, and in vivo animal experiments, have been performed to implement this concept into a viable artificial pump-lung device.RESULTSA series of pump-lung prototypes with a membrane surface area of 0.17 to 0.5 m2were designed and characterized in vitro with bovine blood, demonstrating extremely high gas exchange efficiency. The prototype with a gas exchange surface area of 0.5 m2was evaluated in calves. The device provided oxygen transfer of approximately 115 mL/min for respiratory support of an animal for up to 5 days.CONCLUSIONSProgress to date suggests a high likelihood of success for an extracorporeal shorter-term lung that can be switched in and out like dialysis devices. Our device is unique in that it incorporates an integrated pumping and active mixing principle for excellent gas transfer and eliminates the need of the native right ventricle’s ability to power blood through the artificial and natural lungs.