Comparison of central corneal thickness with four noncontact devices: An agreement analysis of swept-source technology.
Comparison of central corneal thickness with four noncontact devices: An agreement analysis of swept-source technology.
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DOI：
10.4103/ijo.ijo_618_16
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发表时间：
2017-06
影响因子：
3.1
通讯作者：
Özyol P
中科院分区：
文献类型：
--
作者：
Ozyol E;Özyol P
本研究的目的是比较四种非接触式装置在健康眼中的中央角膜厚度（CCT）测量值。在45例健康对照样本中，使用基于扫频源光学相干断层扫描（SS-OCT）、高分辨率旋转Scheimpflug相机系统（Pentacam HR）、带前段模块的谱域OCT（SD-OCT）器械（Spectralis）和非接触式角膜厚度测量（NCP）器械（Topcon TRK-2 P）的光学生物计（IOLMaster 700）测量CCT。使用平均差（即，偏倚）和Bland-Altman分析（95%一致性限（LoA））。SS-OCT光学生物计的平均CCT测量值为537.5 ± 47.5 μm，Scheimpflug系统为532.3 ± 43.8 μm，SD-OCT器械为521.3 ± 44.7 μm，NCP为518.0 ± 43.1 μm（P < 0.001）。SD-OCT设备和NCP显示出最接近的一致性，偏差为2.6 μm（95% LoA，−3.6-8.8 μm），而SS-OCT光学生物计和NCP显示出最不一致性，偏差为18.7 μm（95% LoA，−2.1-39.5 μm）。偏倚为16.1 μm（95% LoA，−3.1-35.3 μm），用于SS-OCT光学生物计和SD-OCT，5.1 μm（95% LoA，−6.8-17.0 μm），用于SS-OCT光学生物计和Scheimpflug系统，10.9 μm（95% LoA，−15.1-36.9 μm），Scheimpflug系统和NCP为13.6 μm（95% LoA，−5-32.2 μm）。与Scheimpflug系统、SD-OCT器械和NCP相比，SS-OCT光学生物测定仪高估CCT测量值。鉴于器械之间CCT测量值的平均差异和范围变化，SS-OCT光学生物计和Scheimpflug系统可互换，SD-OCT和NCP也是如此。
The purpose of this study was to compare the central corneal thickness (CCT) measurements of four noncontact devices in healthy eyes. In a sample of 45 healthy controls, CCT was measured using an optical biometer (IOLMaster 700) based on swept-source optical coherence tomography (SS-OCT), high-resolution rotating Scheimpflug camera system (Pentacam HR), spectral-domain OCT (SD-OCT) device with an anterior segment module (Spectralis), and noncontact pachymetry (NCP) device (Topcon TRK-2P). Agreement among the devices was analyzed using mean differences (i.e., bias) and Bland–Altman analysis with 95% limits of agreement (LoA). Mean CCT measurements were 537.5 ± 47.5 μm for SS-OCT optical biometer, 532.3 ± 43.8 μm for Scheimpflug system, 521.3 ± 44.7 μm for SD-OCT device, and 518.0 ± 43.1 μm for NCP (P < 0.001). The SD-OCT device and NCP showed the closest agreement, with a bias of 2.6 μm (95% LoA, −3.6–8.8 μm), whereas the SS-OCT optical biometer and NCP showed the least agreement, with a bias of 18.7 μm (95% LoA, −2.1–39.5 μm). Bias was 16.1 μm (95% LoA, −3.1–35.3 μm) for SS-OCT optical biometer and SD-OCT, 5.1 μm (95% LoA, −6.8–17.0 μm) for SS-OCT optical biometer and Scheimpflug system, 10.9 μm (95% LoA, −15.1–36.9 μm) for SD-OCT device and Scheimpflug system, and 13.6 μm (95% LoA, −5–32.2 μm) for Scheimpflug system and NCP. SS-OCT optical biometer overestimates CCT measurements compared to Scheimpflug system, SD-OCT device, and NCP. Given mean differences and range variations in CCT measurements between devices, SS-OCT optical biometer and Scheimpflug system are interchangeable as are SD-OCT and NCP.