The epidemiology of obesity
The epidemiology of obesity
复制标题
DOI：
10.1016/j.metabol.2018.09.005
复制
发表时间：
2019-03-01
影响因子：
9.8
通讯作者：
Magkos, Faidon
中科院分区：
文献类型：
--
作者：
Chooi, Yu Chung;Ding, Cherlyn;Magkos, Faidon
肥胖是一种复杂的多因素疾病。自1980年以来，世界范围内超重和肥胖的流行率翻了一番，以至于世界上近三分之一的人口现在被归类为超重或肥胖。无论地理位置、种族或社会经济地位如何，所有年龄和男女的肥胖率都有所增加，尽管老年人和妇女的肥胖率普遍较高。这一趋势在各区域和国家之间是相似的，尽管超重和肥胖的绝对流行率差别很大。在一些发达国家，肥胖症的流行率在过去几年中似乎趋于稳定。在流行病学研究中，体重指数（BMI）通常用于定义超重和肥胖。然而，BMI具有低敏感性，并且对于任何给定的BMI值，体脂百分比存在较大的个体间变异性，部分归因于年龄，性别和种族。例如，对于相同的BMI，亚洲人的身体脂肪百分比高于白人。更大的心脏代谢风险也与内脏脂肪组织和异位贮库（如肌肉和肝脏）中多余脂肪的定位有关，以及在脂肪与瘦体重比增加的情况下（如正常体重的代谢性肥胖）。这些数据表明，肥胖可能比大型流行病学研究表明的要普遍得多，需要更紧迫的关注。仅仅依靠BMI来评估其患病率可能会阻碍未来针对肥胖预防和控制的干预措施。(C)2018爱思唯尔公司All rights reserved.
Obesity is a complex multifactorial disease. The worldwide prevalence of overweight and obesity has doubled since 1980 to an extent that nearly a third of the world's population is now classified as overweight or obese. Obesity rates have increased in all ages and both sexes irrespective of geographical locality, ethnicity or socioeconomic status, although the prevalence of obesity is generally greater in older persons and women. This trend was similar across regions and countries, although absolute prevalence rates of overweight and obesity varied widely. For some developed countries, the prevalence rates of obesity seem to have levelled off during the past few years. Body mass index (BMI) is typically used to define overweight and obesity in epidemiological studies. However, BMI has low sensitivity and there is a large inter-individual variability in the percent body fat for any given BMI value, partly attributed to age, sex, and ethnicity. For instance, Asians have greater percent body fat than Caucasians for the same BMI. Greater cardiometabolic risk has also been associated with the localization of excess fat in the visceral adipose tissue and ectopic depots (such as muscle and liver), as well as in cases of increased fat to lean mass ratio (e.g. metabolically-obese normal-weight). These data suggest that obesity may be far more common and requires more urgent attention than what large epidemiological studies suggest. Simply relying on BMI to assess its prevalence could hinder future interventions aimed at obesity prevention and control. (C) 2018 Elsevier Inc. All rights reserved.