POLYMERIZATION OF MEMBRANE-COMPONENTS IN AGING RED-BLOOD-CELLS
POLYMERIZATION OF MEMBRANE-COMPONENTS IN AGING RED-BLOOD-CELLS
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DOI：
10.1016/0006-291x(80)91545-4
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发表时间：
1980-01-01
影响因子：
3.1
通讯作者：
HOCHSTEIN, P
中科院分区：
文献类型：
--
作者：
JAIN, SK;HOCHSTEIN, P
在体外红细胞中加入丙二醛可形成内源性膜磷脂过氧化过程中产生的荧光色脂。凝胶电泳显示，该试剂还导致光谱蛋白1和2带的减少以及高分子量蛋白聚合物的增加。从新鲜抽取的未经处理的血液中分离出的老年细胞群的细胞膜也观察到同样的变化。膜组分的聚合，随后的膜脂过氧化，可能有助于改变老化细胞的生化和机械性能，并最终隔离它们。
The addition of malonyldialdehyde to red blood cells in vitro causes the formation of fluorescent chromolipids characteristic of those produced during the peroxidation of endogenous membrane phospholipids. Gel electrophoresis reveals that this agent also causes a decrease in bands 1 and 2 of spectrin as well as an increase in high MW protein polymers. These same changes are observed in membranes of older cell populations fractionated from freshly drawn, untreated blood. Polymerization of membrane components, subsequent to the peroxidation of membrane lipids, may contribute to the altered biochemical and mechanical properties of aging cells and to their eventual sequestration.