Spatial view cells in the primate hippocampus: effects of removal of view details.
Spatial view cells in the primate hippocampus: effects of removal of view details.
复制标题
灵长类海马体中的空间视图细胞：移除视图细节的影响。
DOI：
10.1152/jn.1998.79.3.1145
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发表时间：
1998
影响因子：
2.5
通讯作者：
Pierre Georges‐François
中科院分区：
文献类型：
--
作者：
Robert G. Robertson;E. T. Rolls;Pierre Georges‐François
通过记录实验室中活跃行走的猕猴的海马形成神经元的记录来分析海马功能。分析了“空间视图”细胞，当猴子观察环境的一部分时，这些细胞会做出反应。结果表明，当视图细节被窗帘和黑暗完全遮挡时，许多这些单元保留了它们的空间特征。结果表明，当猴子凝视房间中的一个位置时，许多细胞的反应比其他位置的反应更大，即使看不到任何视图细节。这些细胞存在于 CA1 区、海马旁回和前下托中。当猴子看向环境中通常有效的位置（如果视图细节被遮挡）时，其他细胞会停止响应。这些细胞位于海马体的 CA3 区域。结果表明，对于 CA3 细胞来说，视觉输入对于神经元的正常空间反应是必要的，而对于灵长类海马结构中的其他细胞来说，反应仍然取决于当视图细节模糊时猴子凝视空间中的该位置。因此，后面的这些细胞可以反映记忆系统的操作，其中神经元活动可以由可能不仅包括眼睛位置命令/反馈信号，还可能包括前庭和/或本体感受输入的因素触发。这种“外面”的空间表示将是灵长类记忆系统的适当部分，涉及在环境中何处看到物体的记忆，更一般地，在特定事件或情节的记忆中，空间成分通常为其提供部分上下文。
Hippocampal function was analyzed by making recordings from hippocampal formation neurons in macaques actively walking in the laboratory. "Spatial view" cells, which respond when the monkey looks at a part of the environment were analyzed. It is shown that many of these cells retain their spatial characteristics when the view details are obscured totally by curtains and by darkness. It is shown that many of these cells respond more when the monkey is gazing toward one location in the room than toward other locations, even though none of the view details can be seen. Such cells were found in the CA1 region, the parahippocampal gyrus, and the presubiculum. Other cells stopped responding when the monkey looked toward the normally effective location in the environment if the view details were obscured. These cells were in the CA3 region of the hippocampus. The results indicate that for CA3 cells, the visual input is necessary for the normal spatial response of the neurons, and for other cells in the primate hippocampal formation, the response still depends on the monkey gazing toward that location in space when the view details are obscured. These latter cells therefore could reflect the operation of a memory system, in which the neuronal activity can be triggered by factors that probably include not only eye position command/feedback signals, but also probably vestibular and/or proprioceptive inputs. This representation of space "out there" would be an appropriate part of a primate memory system involved in memories of where in an environment an object was seen and more generally in the memory of particular events or episodes for which a spatial component normally provides part of the context.