White blood cell count as a risk factor for hypertension; a study of Japanese male office workers
White blood cell count as a risk factor for hypertension; a study of Japanese male office workers
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DOI：
10.1097/00004872-200205000-00018
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发表时间：
2002-05-01
影响因子：
4.9
通讯作者：
Tatara, K
中科院分区：
文献类型：
--
作者：
Nakanishi, N;Sato, M;Tatara, K
目的探讨白色血细胞（WBC）计数与高血压发病风险的关系。2900无高血压[收缩压（SBP）< 140 mmHg，舒张压（DBP）< 90 mmHg，无高血压药物治疗，且无高血压病史]男性接受了为期4年的随访。主要结果测量血压水平和高血压发生率（收缩压大于或等于140 mmHg和/或舒张压大于或等于90 mmHg或药物治疗高血压）。结果在控制了高血压的潜在预测因素后，随着WBC计数的增加，从不吸烟者和戒烟者的SBP和DBP水平均以剂量依赖性方式增加。在目前吸烟者中，只有SBP水平随着WBC计数水平进行性升高。与第一个WBC计数五分位数相比，从不吸烟者发生高血压的多变量校正相对风险分别为1.29、1.21、1.67和1.92（趋势P = 0.002）：在第二、第三、第四和第五个五分位数的戒烟者中分别为1.34、1.46、1.84和1.97（趋势P = 0.030）。在当前吸烟者中，相对于第一个WBC计数五分位数，高血压的多变量校正相对风险分别为0.91、0.97、1.08和0.84（趋势P = 0.999）。结论白细胞计数是高血压的重要危险因素，白细胞计数增加高血压的危险性在不吸烟者中更为明显。J Hypertens 20：851-857（C）2002 Lippincott威廉姆斯威尔金斯。
Objective To investigate the association of white blood cell (WBC) count with risk of hypertension.Design Cross-sectional and longitudinal studies.Setting A work site in Japan.Participants A total of 3776 Japanese male office workers aged 23-49 years were enrolled in this study; 2900 hypertension-free [systolic blood pressure (SBP) < 140 mmHg, diastolic blood pressure (DBP) < 90 mmHg, no medication for hypertension, and no past history of hypertension] men were followed up over a 4-year period.Main outcome measures Blood pressure levels and the incidence of hypertension (SBP greater than or equal to 140 mmHg and/or DBP greater than or equal to 90 mmHg or medication for hypertension) according to WBC count at study entry.Results After controlling for potential predictors of hypertension, SBP and DBP levels increased in a dose-dependent manner among both never-smokers and ex-smokers as WBC count increased. Among current smokers, only SBP level increased progressively with WBC count level. The multivariate-adjusted relative risk for development of hypertension compared with the first WBC count quintile was 1.29, 1.21, 1.67, and 1.92 among never-smokers (P for trend = 0.002): and 1.34, 1.46, 1.84, and 1.97 among ex-smokers (P for trend = 0.030) with the second, third, fourth, and fifth quintiles, respectively. Among current smokers, the respective multivariate-adjusted relative risks for hypertension relative to the first WBC count quintile were 0.91, 0.97, 1.08, and 0.84 (P for trend = 0.999). Conclusions WBC count is an important risk factor for hypertension, and the increased risk for hypertension associated with WBC count is more pronounced in nonsmokers. J Hypertens 20:851-857 (C) 2002 Lippincott Williams Wilkins.