Functional Magnetic Resonance Imaging of Cognitive Processing in Young Adults With Down Syndrome
Functional Magnetic Resonance Imaging of Cognitive Processing in Young Adults With Down Syndrome
复制标题
DOI：
10.1352/1944-7558-116.5.344
复制
发表时间：
2011-09-01
影响因子：
2.1
通讯作者：
Schapiro, Mark B.
中科院分区：
文献类型：
--
作者：
Jacola, Lisa M.;Byars, Anna W.;Schapiro, Mark B.
作者使用功能性磁共振成像（fMRI）研究了13名唐氏综合征患者和12名典型发育对照参与者（年龄范围= 12-26岁）在语义分类/物体识别任务期间的神经激活。组间比较表明唐氏综合症患者的大脑激活模式不典型。视觉空间能力指数与大脑激活之间的相关性分析显示，（a）该指数与典型发育个体的枕叶和顶叶区域的大脑激活之间存在正相关关系，（B）与唐氏综合征个体的额中回和额背回之间存在正相关关系。这些发现支持了作者的假设，即与正常发育的个体相比，唐氏综合征患者表现出非典型的神经激活。
The authors used functional magnetic resonance imaging (fMRI) to investigate neural activation during a semantic-classification/object-recognition task in 13 persons with Down syndrome and 12 typically developing control participants (age range = 12-26 years). A comparison between groups suggested atypical patterns of brain activation for the individuals with Down syndrome. Correlation analyses between an index of visual spatial ability and brain activation depicted a positive relationship between (a) this index and brain activation in regions of the occipital and parietal lobes for the typically developing individuals and (b) the middle and dorsal frontal gyri in the individuals with Down syndrome. These findings supported the authors' hypothesis that persons with Down syndrome demonstrate atypical neural activation compared with typically developing individuals matched for chronological age.