Role of Rho GTPases and their regulators in cancer progression
Role of Rho GTPases and their regulators in cancer progression
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DOI：
10.2741/3872
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发表时间：
2011-06-01
影响因子：
3.1
通讯作者：
Alahari, Suresh K.
中科院分区：
文献类型：
--
作者：
Rathinam, Rajamani;Berrier, Allison;Alahari, Suresh K.
GTPases 的 Rho 家族是一个普遍表达且进化保守的 GTP 结合蛋白家族，可调节肌动蛋白动力学和细胞内信号传导。在 Rho 家族 GTPases 中，三个成员 RhoA、Rac1 和 CDC42 已得到很好的表征。它们各自在基因表达、细胞增殖、细胞凋亡和各种细胞功能中发挥着关键作用。它们由 RhoGDI、RhoGEF、RhoGAP 和细胞表面受体的信号驱动。 Rho GTP 酶功能异常会对细胞行为产生重大影响。 Rho GTPases 的过度表达与肌动蛋白细胞骨架的重组、细胞迁移、侵袭和转移的增加有关，这些都是癌症进展的重要方面。本综述将探讨这些 Rho GTP 酶及其相关信号通路在不同类型癌症中的功能。
Rho family of GTPases is an ubiquitiously expressed and evolutionarily conserved family of GTP binding proteins that regulate actin dynamics and intracellular signaling. Among the Rho family GTPases, three members RhoA, Rac1 and CDC42 have been well characterized. They each play pivotal roles in gene expression, cell proliferation, apoptosis and various cellular functions. They are driven by signaling from RhoGDIs, RhoGEFs, RhoGAPs and cell surface receptors. Abnormalities in Rho GTPase function have major consequences on cell behavior. Over expression of Rho GTPases is associated with reorganization of actin cytoskeleton, an increase in cell migration, invasion and metastasis which are important aspects of cancer progression. This review will explore these Rho GTPases and the function of their associated signaling pathways in different types of cancers.