Is Alexithymia Related to Negative Symptoms of Schizophrenia?
Is Alexithymia Related to Negative Symptoms of Schizophrenia?
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DOI：
10.1159/000088919
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发表时间：
2005-11
期刊：
影响因子：
3.6
通讯作者：
O. Todarello;P. Porcelli;F. Grilletti;A. Bellomo
中科院分区：
文献类型：
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作者：
O. Todarello;P. Porcelli;F. Grilletti;A. Bellomo
背景：述情特征与精神分裂症阴性症状的快感缺乏、情感迟钝和痛症相似。本研究旨在评估述情障碍是否与阴性症状相关，并与精神分裂症症状随时间的变化有关。抽样和方法：对29名精神分裂症门诊患者进行连续抽样，分别在基线和适当治疗期间的3、6和12个月进行评估。他们在任何时间点完成了积极和消极综合症量表、蒙哥马利和阿斯伯格抑郁评定量表、整体功能评估量表和20项多伦多述情障碍量表。结果：随着时间的推移，精神病学量表得分显示出显著的症状改善，但与述情障碍评分无关，述情障碍评分随着时间的推移而稳定。层次回归显示，在控制了精神病理和心理功能后，基线时的20项多伦多述情量表是12个月时述情障碍的唯一预测因子。结论：述情障碍与阴性症状无关，提示述情障碍与精神分裂症是一个独立的概念。正如预期的那样，阴性症状与疾病相关的抑郁和心理社会功能有关。在概括时要谨慎，主要是因为本研究受限于样本量小。
Background: Alexithymic features are close to anhedonia, blunted affect, and alogia that are also characteristics of the negative symptoms of schizophrenia. This study aimed to evaluate whether alexithymia is associated with negative symptoms and is related to the change of schizophrenic symptoms over time. Sampling and Methods: A consecutive sample of 29 schizophrenic outpatients was evaluated at baseline and at 3, 6, and 12 months during appropriate treatment. They completed the Positive and Negative Syndrome Scale, the Montgomery and Asberg Depression Rating Scale, the Global Assessment of Functioning Scale, and the 20-item Toronto Alexithymia Scale at any time points. Results: The psychiatric scale scores showed significant symptom improvement over time but were unrelated to the alexithymia score that was instead stable over time. Hierarchical regression showed that the 20-item Toronto Alexithymia Scale at baseline was the sole predictor of alexithymia at 12 months, after controlling for psychopathology and psychological functioning. Conclusions: Alexithymia was unrelated to negative symptoms, suggesting it is an independent and separate construct from schizophrenia. As expected, the negative symptoms were associated instead with illness-related aspects of depression and psychosocial functioning. Caution should be expressed in generalization mainly because this study is limited by the small sample size.