Interactions of anti-inflammatory drugs in carrageenan-induced foot edema of the rat.
Interactions of anti-inflammatory drugs in carrageenan-induced foot edema of the rat.
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抗炎药物在角叉菜胶引起的大鼠足部水肿中的相互作用。
DOI：
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发表时间：
1970
影响因子：
3.5
通讯作者：
D. Kvam
中科院分区：
文献类型：
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作者：
K. Swingle;T. J. Grant;L. W. Jaques;D. Kvam
采用角叉菜胶诱导的大鼠足肿胀模型，观察了非甾体非甾体抗炎药与非甾体抗炎药合用对大鼠足肿胀的影响。醋酸氢化可的松和苯丁酮、阿司匹林或消炎痛的联合作用明显大于相应剂量的每种成分药物所产生的作用。在任何情况下，两种非类固醇药物的组合产生的效果都不会比在相应剂量下单独给予任何一种非类固醇药物产生的效果更大。因此，当氢化可的松与另一种非类固醇抗炎药同时给药时，“节制”活性可能归因于非类固醇类药物。
The effect of nonsteroidal-nonsteroidal and nonsteroidal-steroidal anti-inflamrnatory drug combinations on carrageenan-induced foot edema of the rat was examined. The resultant effect of combinations of hydrocortisone acetate and phenylbutazone, aspirin or indomethacin was significantly greater than the effect produced by each of the component drugs at corresponding doses. In no case did a combination of two nonsteroidal drugs give an effect greater than that produced by either one of the non-steroids given alone at the corresponding dose. Thus, "sparing" activity may be ascribed to a non-steroid when given with hydrocortisone but not when it is given together with a second nonsteroidal anti-inflammatory drug in this assay.