High Levels of Serum Uric Acid Predict Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome
High Levels of Serum Uric Acid Predict Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome
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DOI：
10.1177/0003319711426868
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发表时间：
2012-08-01
期刊：
影响因子：
2.8
通讯作者：
Kaya, Mehmet Gungor
中科院分区：
文献类型：
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作者：
Duran, Mustafa;Kalay, Nihat;Kaya, Mehmet Gungor
我们的目的是阐明患有急性冠状动脉综合征 (ACS) 的非糖尿病、非高血压患者 (n = 246) 的血清尿酸 (SUA) 水平与冠状动脉疾病 (CAD) 严重程度之间的关系。 CAD的严重程度通过Gensini评分来评估。分别有 87 名 (35.4%)、55 名 (22.4%) 和 104 名 (42.2%) 患者发现 1 条、2 条和 3 条或更多病变血管。高尿酸血症患者Gensini评分较高，病变血管数量较多，病变严重，完全闭塞。血清尿酸水平与病变血管数量显着相关。单因素分析表明血清尿酸是多支血管病变的独立危险因素。在患有 ACS 的非糖尿病、非高血压患者中，高水平的 SUA 与 CAD 的严重程度相关。
We aimed to elucidate the relation between serum uric acid (SUA) level and severity of coronary artery disease (CAD) in nondiabetic, nonhypertensive patients (n = 246) with acute coronary syndrome (ACS). Severity of CAD was assessed by the Gensini score. One, 2, and 3 or more diseased vessels were identified in 87 (35.4%), 55 (22.4%), and 104 (42.2%) patients, respectively. Patients with hyperuricemia had higher Gensini score, high number of diseased vessels, critical lesions, and total occlusion. Serum uric acid level was significantly associated with number of diseased vessels. Serum uric acid was an independent risk factor for multivessel disease by univariate analysis. High levels of SUA associated with the severity of CAD in nondiabetic, nonhypertensive patients with ACS.