Fungi of the genus Penicillium as producers of physiologically active compounds (Review)
Fungi of the genus Penicillium as producers of physiologically active compounds (Review)
复制标题
DOI：
10.1134/s0003683813010092
复制
发表时间：
2013-01-01
影响因子：
0.8
通讯作者：
Antipova, T. V.
中科院分区：
文献类型：
--
作者：
Kozlovskii, A. G.;Zhelifonova, V. P.;Antipova, T. V.
从很少研究的栖息地分离出的青霉菌属真菌能够合成具有不同结构的先前已知的和新的生理活性化合物。它们包括生物碱性质的次生代谢物，即麦角生物碱、二酮哌嗪、喹啉、喹唑啉、苯二氮卓类和聚酮化合物。我们讨论了次级代谢物概况用于分类学目的的用途。研究生物活性化合物生产者的理化特性表明，生物碱的生物合成在培养的第一天就开始，并与生长同时进行。记录了与生物碱生物合成、细胞排泄、培养液降解和细胞消耗过程相关的生物碱积累的循环特征。细胞内色氨酸和生物碱浓度的同步变化对于调节培养所需色氨酸的最佳量是必要的。
Fungi of the genus Penicillium isolated from little studied habitats are able to synthesize both previously known and new physiologically active compounds with diverse structures. They include secondary metabolites of alkaloid nature, i.e., ergot alkaloids, diketopiperazines, quinolines, quinazolines, benzodiazepines, and polyketides. We discuss the use of profiles of secondary metabolites for taxonomy purposes. Studying the physicochemical characteristics of producers of biologically active compounds showed that the biosynthesis of alkaloids is initiated on the first days of cultivation and proceeds simultaneously with growth. The cyclic character of alkaloid accumulation was recorded related to the processes of alkaloid biosynthesis, excretion from cells, degradation in culture fluid, and consumption by cells. Synchronic variations in the concentrations of intracellular tryptophan and alkaloids are necessary for the regulation of the optimal quantity of tryptophan necessary for the culture.