Transcriptional regulation of the anti-inflammatory cytokine IL-10 in acquired immune cells.
Transcriptional regulation of the anti-inflammatory cytokine IL-10 in acquired immune cells.
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DOI：
10.3389/fimmu.2012.00275
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发表时间：
2012
影响因子：
7.3
通讯作者：
Motomura Y
中科院分区：
文献类型：
--
作者：
Kubo M;Motomura Y
虽然免疫反应的主要作用是宿主防御广泛的潜在病原微生物，但过度的免疫反应可导致严重的宿主损伤。因此，宿主需要抗炎机制来防止对自身的反应。白细胞介素-10（IL-10）是一种具有广泛抗炎特性的细胞因子，参与多种疾病的发病机制。IL-10最初被描述为T辅助细胞（TH 2）衍生的细胞因子，但进一步的研究表明IL-10不仅由适应性免疫系统的许多细胞（包括T和B细胞）表达，而且由先天性免疫细胞（包括树突状细胞（DC）、巨噬细胞、肥大细胞和自然杀伤（NK）细胞）表达。此外，IL-10可以通过慢性炎症作为反馈调节系统在TH 1和TH 17细胞中诱导。本文就IL 10基因在适应性免疫细胞中表达的分子机制及其表观遗传和转录调控的研究进展作一综述。了解转录调控事件可能有助于开发控制炎症性疾病的新策略。
Although the major role of the immune response is host defense from a wide range of potentially pathogenic microorganisms, excess immune responses can result in severe host damage. The host thus requires anti-inflammatory mechanisms to prevent reactivity to self. Interleukin-10 (IL-10) is a cytokine with broad anti-inflammatory properties involved in the pathogenesis of various diseases. IL-10 was originally described as a T helper (TH2) derived cytokine, but further studies indicated that IL-10 is expressed not only by many cells of the adaptive immune system, including T and B cells, but also by the innate immune cells, including dendritic cells (DCs), macrophages, mast cells, and natural killer (NK) cells. In addition, IL-10 can be induced in TH1 and TH17 cells by chronic inflammation as a system of feedback regulation. In this review, we focus on the molecular mechanisms underlying IL10 gene expression in adaptive immune cells and summarize the recent progresses in epigenetic and transcriptional regulation of the IL10 gene. Understanding the transcriptional regulatory events may help in the development of new strategies to control inflammatory diseases.