Antiplasmodial activities of ethanol extracts of Euphorbia hirta whole plant and Vernonia amygdalina leaves in Plasmodium berghei-infected mice
Antiplasmodial activities of ethanol extracts of Euphorbia hirta whole plant and Vernonia amygdalina leaves in Plasmodium berghei-infected mice
复制标题
DOI：
10.1016/j.jtusci.2017.01.008
复制
发表时间：
2017-11-01
影响因子：
3.3
通讯作者：
Adeyemi, A. A.
中科院分区：
文献类型：
--
作者：
Ajayi, E. I. O.;Adeleke, M. A.;Adeyemi, A. A.
非洲大陆拥有丰富的动植物资源，在当地被广泛用于治疗或治愈各种疾病。对传统民间传说的调查显示，一品红和杏花除具有抗疟原虫特性外，还具有治疗发热的作用。因此，我们用标准程序研究了大戟全草(CEEH)和杏花叶(CEVA)的粗乙醇提取物的植物化学、抗疟疾效力、肝毒性和肾毒性。结果表明，CEEH和CEVA中含有黄酮类、生物碱、单宁和皂苷，但不含白果单宁。CEEH和CEVA对伯氏疟原虫裂殖体成熟的抑制作用较弱(分别为44.36%和37.85%)，而青蒿琥酯联合疗法(ACT)对氯喹敏感伯氏原虫的抑制作用较弱(50%)。CEEH显著降低ALP，但显著升高胆红素。与未经治疗的感染动物相比，这两种提取物都显著提高了白蛋白和总蛋白水平。与Camosunate(R)相比，CEVA导致肌酐和尿素进一步显著增加。然而，这些增加并不意味着器官受损。(C)2017年作者。爱思唯尔公司代表泰霸大学制作和主办。这是一篇CC BY-NC-ND许可证下的开放访问文章
The African continent is rich in both flora and fauna resources, which have been extensively used locally in the treatment or cure of a wide variety of ailments. Enquiries into traditional folklore revealed that Euphorbia hirta and Vernonia amygdalina possess antiplasmodial properties among others for the treatment of febrile conditions. We therefore investigated the phytochemistry, antimalarial potencies, hepatic toxicities and renal toxicities of the crude ethanol extract of the whole plant of Euphorbia hirta( CEEH) and leaves of Vernonia amygdalina (CEVA) using standard procedures. The obtained results showed that CEEH and CEVA contain flavonoids, alkaloids, tannins and saponins, but not phlobatannins. CEEH and CEVA mildly inhibited P. berghei schizont maturation (44.36% and 37.85%, respectively), while Artesunate Combination Therapy (ACT) was only slightly potent (>50%) against chloroquine-sensitive P. berghei. CEEH significantly decreased ALP, but significantly increased bilirubin. Both extracts significantly increased the albumin and total protein levels compared to infected, untreated animals. Compared to Camosunate (R), CEVA caused further significant increases in creatinine and urea. However, these increases did not indicate organ damage. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of Taibah University. This is an open access article underthe CC BY-NC-ND license