A family of Turandot-related genes in the humoral stress response of Drosophila
A family of Turandot-related genes in the humoral stress response of Drosophila
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DOI：
10.1006/bbrc.2001.5067
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发表时间：
2001-06-22
影响因子：
3.1
通讯作者：
Hultmark, D
中科院分区：
文献类型：
--
作者：
Ekengren, S;Hultmark, D
果蝇Turandot A（TotA）基因最近被证明编码一种应激诱导的体液因子，该因子增加了对高温致死效应的抗性。在这里，我们表明，TotA属于一个家庭的8个Tot基因分布在三个不同的网站在果蝇基因组。所有的Tot基因在压力条件下，如细菌感染，热休克，百草枯喂养或暴露于紫外线下诱导，这表明该家族的所有成员在果蝇应激耐受性中发挥作用。Tot基因的诱导在重要方面与热休克反应不同，例如几个基因对细菌感染的强烈但延迟的反应。(C)北京：科学出版社.
The Drosophila Turandot A (TotA) gene was recently shown to encode a stress-induced humoral factor which gives increased resistance to the Lethal effects of high temperature. Here we show that TotA belongs to a family of eight Tot genes distributed at three different sites in the Drosophila genome. All Tot genes are induced under stressful conditions such as bacterial infection, heat shock, paraquat feeding or exposure to ultraviolet light, suggesting that all members of this family play a role in Drosophila stress tolerance. The induction of the Tot genes differs in important respects from the heat shock response, such as the strong but delayed response to bacterial infection seen for several of the genes. (C) 2001 Academic Press.