Fractional Anisotropy in the Posterior Limb of the Internal Capsule and Prognosis in Amyotrophic Lateral Sclerosis
Fractional Anisotropy in the Posterior Limb of the Internal Capsule and Prognosis in Amyotrophic Lateral Sclerosis
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DOI：
10.1001/archneurol.2012.1122
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发表时间：
2012-11-01
影响因子：
--
通讯作者：
Turner, Martin R.
中科院分区：
文献类型：
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作者：
Menke, Ricarda A. L.;Abraham, Ivy;Turner, Martin R.
目的：探讨扩散张量成像应用于那些特定的大脑白色物质束一贯参与病理肌萎缩侧索硬化症作为一个来源的预后biomarkers.Design的价值：基线临床评估和3-T扩散张量成像，重复约6个月后。基于道的空间统计被用来评估基线弥散张量成像指数与进展率的体素相关性。患者：该研究涉及21名肌萎缩侧索硬化症患者和3名原发性侧索硬化症患者。结果：在跨越内囊后肢的皮质脊髓束区域，观察到分数各向异性和进展率之间的相关性，强调左半球。内囊后肢各向异性分数显示出区分快速进展患者的潜力。在基线和随访扩散张量成像的配对t检验分析中，该区域的轴向扩散率显著增加，与轴突损伤一致。没有相关性注意到胼胝体。结论：后肢内囊分数各向异性是一个候选的肌萎缩侧索硬化症的预后标志物，有可能确定事件的情况下，更快速的进展。
Objective: To explore the value of diffusion tensor imaging applied to those specific cerebral white matter tracts consistently involved pathologically in amyotrophic lateral sclerosis as a source of prognostic biomarkers.Design: Baseline clinical assessment and 3-T diffusion tensor imaging, repeated after approximately 6 months. Tract-based spatial statistics were used to assess voxel-wise correlations of just the baseline diffusion tensor imaging indices with the progression rate (change in disability score/time interval) within the corticospinal tract and corpus callosum.Patients: The study involved 21 patients with amyotrophic lateral sclerosis and 3 patients with primary lateral sclerosis.Results: Correlation was observed between fractional anisotropy and progression rate for a region of the corticospinal tract spanning the posterior limb of the internal capsule, with a left hemisphere emphasis. Posterior limb of the internal capsule fractional anisotropy showed potential to distinguish those patients with rapid progression. Axial diffusivity significantly increased in this region in a paired t test analysis of baseline and follow-up diffusion tensor imaging, in keeping with axonal damage. No correlations were noted for the corpus callosum.Conclusions: Posterior limb of the internal capsule fractional anisotropy is a candidate prognostic marker in amyotrophic lateral sclerosis, with potential to identify incident cases with more rapid progression.