Fat mass rather than muscle strength is the major determinant of physical function and disability in postmenopausal women younger than 75 years of age
Fat mass rather than muscle strength is the major determinant of physical function and disability in postmenopausal women younger than 75 years of age
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DOI：
10.1097/01.gme.0000222331.23478.ec
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发表时间：
2006-05-01
影响因子：
2.7
通讯作者：
Lamberts, Steven W.
中科院分区：
文献类型：
--
作者：
Lebrun, Corinne E. I.;van der Schouw, Yvonne T.;Lamberts, Steven W.
目的：很少有研究调查绝经后妇女的身体成分、功能能力和年龄相关性残疾之间的关系。我们调查了一组年龄小于75岁的健康绝经后妇女的脂肪质量、瘦质量和肌肉力量在残疾发生中的相对作用。设计：我们对396名年龄在56-73岁的独立生活的妇女进行了横断面研究，随机选择了绝经后8-30年之间的妇女。采用双能X线骨密度仪测定瘦肉量和脂肪量。用测功法评估肌肉力量(握力和腿部伸展)。结果：43.7%的受试者超重(25&>=BMI=30 kg/m(2))。肌肉力量随着瘦体重的增加而增加，肌肉力量越大的参与者在体能得分和日常生活能力方面得分越高。较高的脂肪质量与较低的体能得分、较少的体力活动和较高的残疾频率显著相关。脂肪量的增加与瘦肉量的增加和瘦肉/脂肪比的降低有关。与高脂肪质量相关的瘦质量和肌肉力量的增加主要局限在腿部。结论：我们的结果支持脂肪质量作为残疾的主要危险标志的作用，随着年龄的增长，瘦质量的减少和75岁后骨质疏松症的发展，这种作用可能会加速。
Objective: Few studies have investigated the relationships between body composition, functional ability, and age-related disability in postmenopausal women. We investigated the relative role of fat mass, lean mass, and muscle strength in the development of disability in a group of healthy postmenopausal women younger than 75 years.Design: We performed a cross-sectional study among 396 independently living women aged 56-73 years, randomly selected between 8 and 30 years after menopause. Lean mass and fat mass were assessed by dual-energy x-ray absorptiometry. Muscle strength (grip and leg extensors) was assessed using dynamometry. Functional ability was estimated by Physical Performance Score, physical activity during the preceding year, and impairment in activities of daily living.Results: Of the participants, 43.7% were overweight (25 >= BMI= 30 kg/m(2)). Higher muscle strength was observed with increasing lean body mass, and participants with higher muscle strength scored better in the physical performance score and activities of daily living. Higher fat mass was significantly associated with a lower physical performance score, lower physical activity, and a higher frequency of disability. Increasing fat mass was associated with increasing lean mass and decreasing lean/fat ratio. The increase in lean mass and muscle strength associated with higher fat mass was mainly localized in the legs.Conclusions: Our results support the role of fat mass as the primary risk marker for disability, which might later accelerate by the age-related decrease in lean mass and the development of sarcopenia after the age of 75 years.