Chiral calcium catalysts for asymmetric hydroamination/cyclisation.
Chiral calcium catalysts for asymmetric hydroamination/cyclisation.
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DOI：
10.1039/c1cc11229e
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发表时间：
2011-04
影响因子：
4.9
通讯作者：
James S. Wixey;Benjamin D. Ward
中科院分区：
文献类型：
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作者：
James S. Wixey;Benjamin D. Ward
手性 1,2-二胺负载的钙配合物已被证明是氨基-烯烃底物不对称氢胺化的有效催化剂；钙络合物 [Ca(NN(R)){N(SiMe(3))(2)}(THF)] (R = (t)Bu, (i)Pr, Ph, 4-C(6)H(4)F) 的对映选择性高达 26%，这标志着基于文献优先级的显着增加。 [Ca(NN(Ph)){N(SiMe(3))(2)}(py)] 的结构已用密度泛函方法计算。
Calcium complexes supported by chiral 1,2-diamines have been shown to be efficient catalysts for the asymmetric hydroamination of amino-olefin substrates; the calcium complexes [Ca(NN(R)){N(SiMe(3))(2)}(THF)] (R = (t)Bu, (i)Pr, Ph, 4-C(6)H(4)F) give enantioselectivities of up to 26% which marks a significant increase based upon literature precedence. The structure of [Ca(NN(Ph)){N(SiMe(3))(2)}(py)] has been computed with density functional methods.