FIBRINOGEN AND FIBRINOLYTIC VARIABLES IN RELATION TO ANTHROPOMETRY, LIPIDS AND BLOOD-PRESSURE - THE NORTHERN SWEDEN MONICA STUDY
FIBRINOGEN AND FIBRINOLYTIC VARIABLES IN RELATION TO ANTHROPOMETRY, LIPIDS AND BLOOD-PRESSURE - THE NORTHERN SWEDEN MONICA STUDY
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DOI：
10.1016/0895-4356(94)90298-4
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发表时间：
1994-05-01
影响因子：
7.2
通讯作者：
LUNDBLAD, D
中科院分区：
文献类型：
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作者：
ELIASSON, M;EVRIN, PE;LUNDBLAD, D
纤维蛋白溶解依赖于纤溶酶原激活物（tPA）活性，而高纤维蛋白原水平增加血栓栓塞事件的风险。从1558名年龄在25至64岁的男性和女性的横断面人群样本中，血浆纤维蛋白原，tPA活性和纤溶酶原激活物抑制剂-1（派）活性使用特定的测定。与体重指数（BMI），腰臀比（WHR），血脂和血压的关联进行了计算与单因素和多因素模型，其中还介绍了年龄和吸烟。在男性中，躯干肥胖、身高过矮和低HDL胆固醇独立预测纤维蛋白原（R（2）0.20），而在女性中，肥胖本身、总胆固醇、收缩压、吸烟和年龄是预测因子（R（2）0.29）。tPA活性与BMI和血清甘油三酯水平呈负相关，与年龄呈正相关。男性舒张压（R（2）0.22）和女性腰臀比进一步独立预测低纤溶活性。HDL与女性更大的纤维蛋白溶解相关（R（2）0.15）。与派-1活性的关系基本上是相反的tPA，但更强。需要前瞻性干预研究来回答因果关系的问题。
Fibrinolysis is dependent upon plasminogen activator (tPA) activity while high fibrinogen levels increase the risk of thromboembolic events. From a cross-sectional population sample of 1558 men and women aged 25 to 64 years, plasma fibrinogen, tPA activity and plasminogen activator inhibitor-1 (PAI) activity were determined using specific assays. Associations with body mass index (BMI), waist-hip ratio (WHR), serum lipids and blood pressure were calculated with uni- and multivariate models where age and smoking were also introduced. In men age, truncal obesity, short height and low HDL cholesterol independently predicted fibrinogen (R(2) 0.20) while in women obesity per se, total cholesterol, systolic blood pressure, smoking and age were predictors (R(2) 0.29). tPA activity was negatively associated with BMI and serum triglyceride levels and positively with age in both sexes. In men diastolic blood pressure (R(2) 0.22) and in women WHR further independently predicted low fibrinolytic activity. HDL was associated with greater fibrinolysis in women (R(2) 0.15). Relationships with PAI-1 activity were essentially the reverse of tPA but stronger. Prospective interventional studies are needed to answer the question of causality.