LONG-TERM RETENTION OF IMPLICITLY ACQUIRED LEARNING IN PATIENTS WITH ALZHEIMERS-DISEASE
LONG-TERM RETENTION OF IMPLICITLY ACQUIRED LEARNING IN PATIENTS WITH ALZHEIMERS-DISEASE
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DOI：
10.1080/01688639108405105
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发表时间：
1991-11-01
影响因子：
2.2
通讯作者：
KNOPMAN, D
中科院分区：
文献类型：
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作者：
KNOPMAN, D
本研究采用连续反应时（SRT）任务，在阿尔茨海默病（AD）患者和老年对照（EC）受试者中，检查了延迟1或2周的程序性学习的保留。SRT任务是由100次试验组成的四选择反应时间任务。在第一阶段的前四个试验组和第二阶段的前两个试验组中嵌入了10项重复序列。序列特异性学习进行了评估，在第一届会议通过比较反应时间（RT）在第四块与重复序列的第五块在第一届会议中的刺激是随机排列的。在排除第一阶段学习不足的受试者后，有8名AD患者和14名EC受试者在第一阶段表现出强大的序列特异性学习。在这些受试者中，检查了在1至2周延迟期间序列特异性学习的保留。AD患者和EC受试者在RT中表现出相当的变化，并且所有AD患者都缺乏对任务中重复序列的任何陈述性知识。个别地，八个AD患者中的两个似乎偏离其他人和EC受试者在他们的过度减慢跨会话的RT。由于6例AD患者确实表现出与EC受试者相似的保留，因此可以得出结论，至少有一些AD患者在长时间延迟后表现出对隐式获得的知识的正常保留。在一些AD患者中保留的保留意味着它是由不受阿尔茨海默病神经病理过程影响的脑结构介导的。
This study examined retention of procedural learning, using the serial reaction time (SRT) task, over a 1- or 2-week delay in Alzheimer's disease (AD) patients and elderly control (EC) subjects. The SRT task is a four-choice reaction-time task consisting of blocks of 100 trials. A 10-item repeating sequence was embedded in the first four blocks of trials in session one and the first two blocks of session two. Sequence-specific learning was assessed in session one by comparing reaction time (RT) in the fourth block with a repeating sequence to a fifth block in session one in which the stimuli were randomly arranged. After excluding subjects with deficient session one learning, there were eight AD patients and 14 EC subjects who showed robust sequence-specific learning in session one. In these subjects, retention of sequence-specific leaming over the 1- to 2-week delay was examined. The AD patients and EC subjects showed an equivalent change in RT across sessions, and all the AD patients lacked any declarative knowledge of the repeating sequence within the task. Individually, two of the eight AD patients appeared to deviate substantially from the others and from the EC subjects in their excess slowing of RT across sessions. Since six AD patients did show retention similar to the EC subjects, it is concluded that at least some AD patients show normal retention of implicitly acquired knowledge over a long delay. Preserved retention in some of the AD patients implies that it is mediated by brain structures that are not affected by the Alzheimer neuropathological process.