A Novel Bone Marrow Stimulation Technique Augmented by Administration of Ultrapurified Alginate Gel Enhances Osteochondral Repair in a Rabbit Model
A Novel Bone Marrow Stimulation Technique Augmented by Administration of Ultrapurified Alginate Gel Enhances Osteochondral Repair in a Rabbit Model
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DOI：
10.1089/ten.tec.2015.0128
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发表时间：
2015-12-01
影响因子：
3
通讯作者：
Iwasaki, Norimasa
中科院分区：
文献类型：
--
作者：
Baba, Rikiya;Onodera, Tomohiro;Iwasaki, Norimasa
腕关节损伤是一种常见的健康问题，导致日常活动的损失。骨髓刺激技术是治疗软骨损伤的手术方法之一，具有技术简单、创伤小的特点。然而，它已被证明会导致纤维或纤维软骨修复，长期效果较差。本研究的重点是使用超纯化藻酸盐凝胶（UPAL凝胶）作为辅助支架结合骨髓刺激技术。本研究的目的是评估UPAL凝胶增强骨髓刺激技术在兔骨软骨缺损模型中的有效性。为了实现这一目标，如下制备三个实验组：无干预的缺损、用骨髓刺激技术治疗的缺损和用UPAL凝胶增强的骨髓刺激技术治疗的缺损。术后16周，UPAL凝胶填充的缺损的宏观和组织学表现明显优于其他缺损。与单独的骨髓刺激技术不同，联合技术引起透明样软骨修复。这种联合手术有可能改善使用骨髓刺激技术治疗关节软骨损伤后的临床结局。
Cartilage injuries are a common health problem resulting in the loss of daily activities. Bone marrow stimulation technique, one of the surgical techniques for the cartilage injuries, is characterized by technical simplicity and less invasiveness. However, it has been shown to result in fibrous or fibrocartilaginous repair with inferior long-term results. This study focused on using ultrapurified alginate gel (UPAL gel) as an adjuvant scaffold in combination with a bone marrow stimulation technique. The objective of this study was to assess the efficacy of a bone marrow stimulation technique augmented by UPAL gel in a rabbit osteochondral defect model. To achieve this goal, three experimental groups were prepared as follows: defects without intervention, defects treated with a bone marrow stimulation technique, and defects treated with a bone marrow stimulation technique augmented by UPAL gel. The macroscopic and histological findings of the defects augmented by UPAL gel improved significantly more than those of the others at 16 weeks postoperatively. The combination technique elicited hyaline-like cartilage repair, unlike bone marrow stimulation technique alone. This combination procedure has the potential of improving clinical outcomes after use of a bone marrow stimulation technique for articular cartilage injuries.