Apolipoprotein A5 and triglyceridemia. Focus on the effects of the common variants
Apolipoprotein A5 and triglyceridemia. Focus on the effects of the common variants
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DOI：
10.1515/cclm.2005.153
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发表时间：
2005-01-01
影响因子：
6.8
通讯作者：
Hubacek, JA
中科院分区：
文献类型：
--
作者：
Hubacek, JA
高血浆甘油三酯水平是心血管疾病发展的独立危险因素。载脂蛋白A5（apolipoprotein A5，APOA 5）是通过比较测序发现的载脂蛋白APOA 1/C3/A4基因簇的新成员。转基因小鼠和基因敲除小鼠的建立表明APOA 5基因对于测定血浆甘油三酯水平的重要性（转基因小鼠显示出显著降低的甘油三酯，而敲除小鼠具有高水平的甘油三酯）。现在已经清楚地确定，APOA 5基因中的不同多态性一贯地影响广泛人群中的血浆甘油三酯，本文还对APOA 5变异体在心肌梗死和冠状动脉疾病发生、低密度脂蛋白颗粒大小、血浆C反应蛋白和高密度脂蛋白胆固醇浓度测定中的作用进行了综述。
High plasma levels of triglycerides are an independent risk factor for the development of cardiovascular disease. Apolipoprotein A5 (APOA5) is a new member of the apolipoprotein APOA1/C3/A4 gene cluster, found by comparative sequencing analysis. The importance of the APOA5 gene for determination of plasma triglyceride levels has been suggested by the creation of transgenic and knock-out mice (transgenic mice displayed significantly reduced triglycerides, whereas knock-out mice had a high level of triglycerides).It has now been clearly established that distinct polymorphisms in the APOA5 gene consistently influence plasma triglycerides in a wide range of human populations, although some differences between ethnic groups and males and females were described.The possible roles of APOA5 variants in determining the risk of myocardial infarction and coronary artery disease development, as well as in the determination of low-density lipoprotein-particle size or plasma concentrations of C-reactive protein and highdensity lipoprotein-cholesterol, are also summarized.