A defoaming agent should be used with pronase premedication to improve visibility in upper gastrointestinal endoscopy
A defoaming agent should be used with pronase premedication to improve visibility in upper gastrointestinal endoscopy
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DOI：
10.1055/s-2002-33220
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发表时间：
2002-07-01
期刊：
影响因子：
9.3
通讯作者：
Chuang, CH
中科院分区：
文献类型：
--
作者：
Kuo, CH;Sheu, BS;Chuang, CH
背景和研究目的：本研究检测链霉蛋白酶是否能提高内镜下可见度并改变CLO检测H。患者和方法：总共160名患者被随机分配接受五种内镜检查前用药之一：A组：二甲基聚硅氧烷（DMPS）单独; B组：DMPS加水。（最多100 ml）; C组：仅链霉蛋白酶，用水100 ml; D组：链霉蛋白酶和碳酸氢钠加水至100 ml; E组：链霉蛋白酶、碳酸氢钠和DMPS，再加水至100 ml。不知道术前给药方法的内镜医师评估了胃窦、胃体下部、胃体上部和胃底的可见性评分（范围1-4）。分数越高，可见性越不清晰。四个位置的得分总和被定义为总可见性得分。在内窥镜检查期间还进行了CLO试验。结果：C、D、E组患者的总视力评分明显低于其他4组（P <0. 05），C、D、E组患者的总视力评分明显低于其他4组（P <0. 05）。C组和D组的总能见度评分高于其他三组（P < 0.05）。A组和B组之间的评分无显著差异。根据UBT结果，CLO试验的敏感性和特异性分别为92.6%和96.2%，respectives.Conclusions：在E组术前用药提供了最清晰的内镜可视性。如果不应用DMPS，单独使用链霉蛋白酶不能改善内镜可见性。链霉蛋白酶对H.使用CLO测试进行幽门螺杆菌鉴定。
Background and Study Aims: The study tested whether pronase can improve endoscopic visibility and alter the accuracy of the CLO test for H. pylori detection.Patients and Methods: A total of 160 patients were randomly assigned to receive one of five premedications for endoscopy: group A: dimethylpolysiloxane (DMPS) alone; group B: DMPS plus water (up to 100 ml); group C: pronase only, with 100 ml water; group D: pronase and sodium bicarbonate plus water up to 100 ml; group E: pronase, sodium bicarbonate, and DMPS, plus water up to 100 ml. Endoscopists, who were unaware of the premedication method administered, assessed visibility scores (range 1-4) for the antrum, lower gastric body, upper gastric body, and fundus. The higher the score, the less clear the visibility. The sum of scores from the four locations was defined as the total visibility score. A CLO test was also done during the endoscopy. One week after their endoscopy, patients in groups C, D, and E were scheduled for a C-13-urea breath test (UBT).Results: Group E patients had a significantly lower total visibility score than those in the other four groups (P < 0.05). Groups C and D had higher total visibility scores than the other three groups (P < 0.05). The scores did not significantly differ between groups A and B. Based on the UBT results, the sensitivity and specificity of the CLO test were 92.6% and 96.2%, respectively.Conclusions: Premedication as in group E provided the clearest endoscopic visibility. Without the application of DMPS, pronase alone cannot improve endoscopic visibility. Pronase does not influence H. pylori identification using the CLO test.