SIGNIFICANCE OF RABBITS SEPTUM AS A RELAY STATION BETWEEN MIDBRAIN AND HIPPOCAMPUS .2. DIFFERENTIAL INFLUENCE OF DRUGS UPON BOTH SEPTAL CELL FIRING PATTERN AND HIPPOCAMPUS THETA ACTIVITY
SIGNIFICANCE OF RABBITS SEPTUM AS A RELAY STATION BETWEEN MIDBRAIN AND HIPPOCAMPUS .2. DIFFERENTIAL INFLUENCE OF DRUGS UPON BOTH SEPTAL CELL FIRING PATTERN AND HIPPOCAMPUS THETA ACTIVITY
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DOI：
10.1016/0013-4694(62)90031-7
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发表时间：
1962-01-01
期刊：
影响因子：
--
通讯作者：
GOGOLAK, G
中科院分区：
文献类型：
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作者：
STUMPF, C;PETSCHE, H;GOGOLAK, G
调查是在15只未麻醉的、经过消毒的家兔上进行的。研究了不同药物作用下的中隔细胞活性和海马脑电图。Eserine用于诱导海马的θ活动和间隔细胞的突发放电模式。六巴比妥、东莨菪碱、麦角酸二乙胺（LSD）和氨基甲酸乙酯被用来消除这种叶丝氨酸诱导的θ活动。然而，这些药物对间隔细胞活性的作用有显著差异。六巴比妥（30mg /kg）和东莨菪碱（0.3 mg/kg）同时消除间隔细胞的θ节律和规律的爆发放电模式，从而表明对边缘系统皮层下区域有抑制作用。另一方面，LSD （0.1 mg/kg）在不改变间隔爆发活动的情况下消除了θ节律，从而表明对海马体有直接作用。在高剂量的氨基甲酸乙酯（约2gag）后，θ节律消失，而间隔细胞继续放电，尽管频率降低。这表明对皮质下边缘中心有不完全的抑制作用，对海马体也有直接的影响。尼古丁（3 ~ 6 mg/kg）诱导海马癫痫发作电位。间隔细胞的活动可能会也可能不会受到这些癫痫发作电位的影响。海马癫痫电位对间隔细胞活动的影响可能是由于癫痫活动扩散到间隔。
The investigations were carried out on 15 unanesthetized, curarized rabbits. Septal cell activity and hippocampus eeg were studied under the action of various drugs. Eserine was used to induce both theta activity in the hippocampus and burst firing pattern of septal cells. Hexobarbital, scopolamine, lysergic acid diethylamide (LSD), and urethane were used to abolish this eserine-induced theta activity. There is, however, a remarkable difference in the action of these drugs on the septal cell activity. Hexobarbital (30 mg/kg) and scopolamine (0.3 mg/kg) abolish the theta rhythm and the regular burst firing pattern of the septal cells simultaneously, thereby indicating a depressant effect on the subcortical regions of the limbic system. LSD (0.1 mg/kg), on the other hand, abolishes the theta rhythm without changing the septal burst activity, thereby indicating a direct action on the hippocampus. After high doses of urethane (about 2 gAg) the theta rhythm disappears whereas the septal cells continue to discharge in bursts although with decreasing frequency. This indicates an incomplete depressant effect on the subcortical limbic centers and also a direct effect upon the hippocampus. Nicotine (3-6 mg/kg) induces hippocampus seizure potentials. Septal cell activity may or may not be influenced by these seizure potentials. An influence of hippocampus seizure potentials on septal cell activity may be due to a spread of the seizure activity into the septum.