Maximal myocardial blood flow is enhanced by chronic hypoxemia in late gestation fetal sheep.
Maximal myocardial blood flow is enhanced by chronic hypoxemia in late gestation fetal sheep.
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妊娠晚期胎羊的慢性低氧血症会增加最大心肌血流量。
DOI：
10.1152/ajpheart.1992.263.4.h1327
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Thornburg,KL
中科院分区：
文献类型：
--
作者：
Reller,MD;Morton,MJ;Giraud,GD;Wu,DE;Thornburg,KL
最大心肌血流量的测量给出了关于冠状动脉阻力血管的总横截面积的信息。在连续左心房输注腺苷的过程中（60微克·千克-1.分-1），最大心肌血流量测定4胎儿低氧血症至少5-8天（pH = 7.33 +/- 0.01，动脉PCO 2 = 49.8 +/- 4.2 Torr，动脉PO 2 = 16.1 +/- 1.3 Torr，动脉O2浓度= 5.3 +/- 1.2 ml/dl）。将这些数据与按照相同研究方案（pH = 7.38 +/- 0.02，动脉PCO 2 = 43.1 +/- 3.8 Torr，动脉PO 2 = 19.8 +/- 2.0 Torr，动脉O2浓度= 7.9 +/- 1.0 ml/dl）（P < 0.05）的相同仪器组的正常血氧胎儿（n = 7）进行比较。在相似的动脉压下，最大心肌血流量（ml.min-1.100 g组织-1）对于低氧与正常氧胎儿，总心肌为974 +/- 273和630 +/- 181，左心室游离壁为986 +/- 367和602 +/- 192，1，间隔分别为025 +/- 346和614 +/- 178，右心室自由壁分别为1，231 +/- 274和757 +/- 269（P < 0.01）。这些数据表明，胎儿低氧血症可以显着改变冠状动脉血管床，如果得到证实，这将是一个重要的适应在发育中的胎儿。
The measurement of maximal myocardial blood flow gives information about the total cross-sectional area of the coronary resistance vessels. During a continuous left atrial infusion of adenosine (60 micrograms.kg-1.min-1), maximal myocardial blood flow was measured in 4 fetuses hypoxemic for a minimum of 5-8 days (pH = 7.33 +/- 0.01, arterial PCO2 = 49.8 +/- 4.2 Torr, arterial PO2 = 16.1 +/- 1.3 Torr, and arterial concentration of O2 = 5.3 +/- 1.2 ml/dl). These data were compared with an identically instrumented group of normoxemic fetuses (n = 7) following the same study protocol (pH = 7.38 +/- 0.02, arterial PCO2 = 43.1 +/- 3.8 Torr, arterial PO2 = 19.8 +/- 2.0 Torr, and arterial concentration of O2 = 7.9 +/- 1.0 ml/dl) (P < 0.05). At comparable arterial pressures, the maximal myocardial flow (ml.min-1.100 g tissue-1) for hypoxemic vs. normoxemic fetuses was 974 +/- 273 and 630 +/- 181 for the total myocardium, 986 +/- 367 and 602 +/- 192 for the left ventricular free wall, 1,025 +/- 346 and 614 +/- 178 for the septum, and 1,231 +/- 274 and 757 +/- 269 for the right ventricular free wall, respectively (P < 0.01). These data suggest that hypoxemia in the fetus can significantly alter the coronary vascular bed, which, if confirmed, would represent an important adaptation in the developing fetus.